| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Minireviews |
| Article Title |
Advances in bone tissue engineering and three-dimensional printing: Current strategies and future perspectives in orthopaedics
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yu-Hua Ruan, Peng Wang, Xiao-Dong Tang, Qi Zhang, Peng Yan, Yi-Gong Tian, Cheng-Jin Li, Wei-Ping Fu, Rui-Bo Wang and Chang-Jiang Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Henan Province Key Research and Development Program |
231111311000 |
| Henan Provincial Science and Technology Research Project |
232102310411 |
| Henan Province Medical Science and Technology Key Project |
LHGJ20220566, LHGJ20240365 |
| Henan Province Medical Education Research Project |
WJLX2023079 |
| Zhengzhou Medical and Health Technology Innovation Guidance Program |
2024YLZDJH022 |
|
| Corresponding Author |
Chang-Jiang Zhang, Second Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, No. 3 Kangfu Qianjie, Erqi District, Zhengzhou 450052, Henan Province, China. changjiangzhang1968@outlook.com |
| Key Words |
Bone tissue engineering; Scaffold materials; Stem cells; Bone regeneration; Bioprinting; Orthopaedic applications; Clinical translation |
| Core Tip |
The combination of bone tissue engineering and three-dimensional printing presents a powerful strategy for tailored repair of bone defects. By integrating biocompatible scaffolds, stem cells, and bioactive molecules with precise three-dimensional fabrication, it is possible to create constructs that closely replicate native bone structure and support effective regeneration. Recent advances in smart biomaterials and bioprinting techniques have further improved scaffold functionality and therapeutic outcomes. However, challenges, including vascularization, controlled scaffold degradation, and clinical translation, remain to be fully addressed. Ongoing interdisciplinary efforts will be crucial in overcoming these hurdles and advancing these promising technologies into routine orthopaedic care. |
| Publish Date |
2026-03-16 08:15 |
| Citation |
Ruan YH, Wang P, Tang XD, Zhang Q, Yan P, Tian YG, Li CJ, Fu WP, Wang RB, Zhang CJ. Advances in bone tissue engineering and three-dimensional printing: Current strategies and future perspectives in orthopaedics. World J Orthop 2026; 17(3): 113798 |
| URL |
https://www.wjgnet.com/2218-5836/full/v17/i3/113798.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v17.i3.113798 |
