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Articles Published Processes
1/14/2026 8:09:15 AM | Browse: 2 | Download: 14
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Received |
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2025-09-04 03:17 |
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Peer-Review Started |
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2025-09-04 08:30 |
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First Decision by Editorial Office Director |
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2025-10-13 07:26 |
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Return for Revision |
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2025-10-13 07:26 |
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Revised |
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2025-10-26 16:18 |
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Publication Fee Transferred |
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2025-10-27 02:02 |
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Second Decision by Editor |
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2025-11-26 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-03 07:47 |
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Articles in Press |
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2025-12-03 07:47 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-04 00:24 |
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Publish the Manuscript Online |
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2026-01-14 08:09 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Case Report |
| Article Title |
Rabson-Mendenhall syndrome caused by a novel splice-site mutation (c.1123+2 T>C) of insulin receptor: A case report and review of literature
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kun Wang, Juan Zheng, Long-Chao Gu, Rong-Rong Li, Xu-Dong Su, Jie Bai and Lin Liao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xu-Dong Su, Department of Endocrinology and Metabology, Liaocheng People’s Hospital, No. 67 Dongchang West Road, Liaocheng 252000, Shandong Province, China. sxd0080@sina.com |
| Key Words |
Rabson-Mendenhall syndrome; Insulin receptor gene; Splice mutation; Hyperinsulinemia; Case report |
| Core Tip |
Rabson-Mendenhall syndrome is a rare monogenic diabetes caused by insulin receptor gene mutations, with no effective treatment currently available. Early diagnosis is essential for treatment planning and prognosis evaluation. We report a case of Rabson-Mendenhall syndrome where clinical features, whole-exome sequencing, and bioinformatics identified the c.1123+2 T>C mutation as likely pathogenic. Due to severe insulin resistance, a combination of oral hypoglycemic agents with different mechanisms may be appropriate. Novel therapies, such as leptin, hold potential for future research. |
| Publish Date |
2026-01-14 08:09 |
| Citation |
Wang K, Zheng J, Gu LC, Li RR, Su XD, Bai J, Liao L. Rabson-Mendenhall syndrome caused by a novel splice-site mutation (c.1123+2 T>C) of insulin receptor: A case report and review of literature. World J Diabetes 2026; 17(1): 113821 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i1/113821.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i1.113821 |
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