BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
1/14/2026 8:09:15 AM | Browse: 102 | Download: 276
 |
Received |
|
2025-09-04 03:17 |
|
Peer-Review Started |
|
2025-09-04 08:30 |
|
First Decision by Editorial Office Director |
|
2025-10-13 07:26 |
|
Return for Revision |
|
2025-10-13 07:26 |
|
Revised |
|
2025-10-26 16:18 |
|
Publication Fee Transferred |
|
2025-10-27 02:02 |
|
Second Decision by Editor |
|
2025-11-26 02:40 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-12-03 07:47 |
|
Articles in Press |
|
2025-12-03 07:47 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-01-04 00:24 |
|
Publish the Manuscript Online |
|
2026-01-14 08:09 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Case Report |
| Article Title |
Rabson-Mendenhall syndrome caused by a novel splice-site mutation (c.1123+2 T>C) of insulin receptor: A case report and review of literature
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kun Wang, Juan Zheng, Long-Chao Gu, Rong-Rong Li, Xu-Dong Su, Jie Bai and Lin Liao |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Xu-Dong Su, Department of Endocrinology and Metabology, Liaocheng People’s Hospital, No. 67 Dongchang West Road, Liaocheng 252000, Shandong Province, China. sxd0080@sina.com |
| Key Words |
Rabson-Mendenhall syndrome; Insulin receptor gene; Splice mutation; Hyperinsulinemia; Case report |
| Core Tip |
Rabson-Mendenhall syndrome is a rare monogenic diabetes caused by insulin receptor gene mutations, with no effective treatment currently available. Early diagnosis is essential for treatment planning and prognosis evaluation. We report a case of Rabson-Mendenhall syndrome where clinical features, whole-exome sequencing, and bioinformatics identified the c.1123+2 T>C mutation as likely pathogenic. Due to severe insulin resistance, a combination of oral hypoglycemic agents with different mechanisms may be appropriate. Novel therapies, such as leptin, hold potential for future research. |
| Publish Date |
2026-01-14 08:09 |
| Citation |
Wang K, Zheng J, Gu LC, Li RR, Su XD, Bai J, Liao L. Rabson-Mendenhall syndrome caused by a novel splice-site mutation (c.1123+2 T>C) of insulin receptor: A case report and review of literature. World J Diabetes 2026; 17(1): 113821
|
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i1/113821.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i1.113821 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
