BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
12/27/2025 2:50:54 AM | Browse: 0 | Download: 0
 |
Received |
|
2025-09-05 08:55 |
|
Peer-Review Started |
|
2025-09-05 08:55 |
|
First Decision by Editorial Office Director |
|
2025-10-18 02:33 |
|
Return for Revision |
|
2025-10-18 02:33 |
|
Revised |
|
2025-10-28 11:37 |
|
Publication Fee Transferred |
|
2025-11-02 04:06 |
|
Second Decision by Editor |
|
2025-11-14 02:35 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-11-14 08:50 |
|
Articles in Press |
|
2025-11-14 08:50 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-12-16 01:35 |
|
Publish the Manuscript Online |
|
2025-12-27 02:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Mitochondrial dysfunction as a bridge to pathology in acute pancreatitis: From molecular insights to novel therapeutic strategies
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chuan-Chao Xia, Yue Xu, Zhen-Huan Wang and Guo-Qiang Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
8217030254 |
|
| Corresponding Author |
Guo-Qiang Xu, MD, Professor, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. 1193065@zju.edu.cn |
| Key Words |
Acute pancreatitis; Mitochondria; Mitochondrial dysfunction; Molecular mechanism; Treatment |
| Core Tip |
Mitochondrial dysfunction is increasingly recognized as a pivotal initiating factor in acute pancreatitis (AP), preceding trypsin activation and inflammatory amplification. Key mechanisms include calcium overload, oxidative stress, mitochondrial permeability transition pore opening, and impaired mitophagy. This review synthesizes current evidence on mitochondrial dysregulation in AP and highlights emerging therapeutic strategies targeting mitochondrial pathways, offering new avenues for transitioning from supportive care to mechanism-driven precision medicine in AP management. |
| Publish Date |
2025-12-27 02:50 |
| Citation |
Xia CC, Xu Y, Wang ZH, Xu GQ. Mitochondrial dysfunction as a bridge to pathology in acute pancreatitis: From molecular insights to novel therapeutic strategies. World J Gastroenterol 2025; 31(48): 113840 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i48/113840.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i48.113840 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
