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Articles Published Processes
12/11/2025 8:20:58 AM | Browse: 2 | Download: 1
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Received |
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2025-09-05 13:52 |
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Peer-Review Started |
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2025-09-05 13:53 |
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First Decision by Editorial Office Director |
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2025-09-16 07:58 |
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Return for Revision |
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2025-09-16 07:58 |
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Revised |
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2025-09-28 14:40 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-03 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-03 09:45 |
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Articles in Press |
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2025-11-03 09:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-02 01:44 |
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Publish the Manuscript Online |
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2025-12-11 08:20 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Lymphocyte to C-reactive protein ratio as a novel inflammatory biomarker: Validation and clinical relevance as an independent prognostic factor in cholangiocarcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fan Xiao, De-Hua Zhou, Guo-Wei Liu, Chao-Wei Lin, Zi-You Wu, Hua Yu, Wei Gong and Wei-Feng Tan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82170412 |
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| Corresponding Author |
Wei-Feng Tan, MD, PhD, Professor, Hepatobiliary Surgery Center, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincheng Road, Putuo District, Shanghai 200092, China. twf1231@163.com |
| Key Words |
Cholangiocarcinoma; Lymphocyte to C-reactive protein ratio; Overall survival; Surgical site infection; Hospital stay; Prognostic biomarker; Radical resection; Inflammatory response |
| Core Tip |
This pioneering study establishes the lymphocyte to C-reactive protein ratio (LCR) as the first validated inflammatory biomarker for predicting survival and postoperative outcomes in cholangiocarcinoma. We demonstrate that a low preoperative LCR (< 180) independently correlates with a 4.5-fold increase in the risk of prolonged hospitalization, elevated risk of surgical site infections (odds ratio = 4.41), and significantly reduced median survival (14.93 months vs 46.67 months). As a cost-effective prognostic tool, LCR facilitates refined patient stratification, thereby supporting optimized surgical decision-making and postoperative management. |
| Publish Date |
2025-12-11 08:20 |
| Citation |
Xiao F, Zhou DH, Liu GW, Lin CW, Wu ZY, Yu H, Gong W, Tan WF. Lymphocyte to C-reactive protein ratio as a novel inflammatory biomarker: Validation and clinical relevance as an independent prognostic factor in cholangiocarcinoma. World J Gastrointest Oncol 2025; 17(12): 113853 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i12/113853.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i12.113853 |
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