| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Targeting obesity and lipid metabolism profiles to prevent perianal abscesses: A case-control study and Mendelian randomization analysis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Huang-Fu Ma, Jia-Hua Qian, Yi-Hao Chen, Yue Wang, Yan-Mei Wang, Jia-Nan Li, Zhang-Yun Zhou, Jian-Xiong Ma and Xue-Cheng Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81804092 |
| Young Elite Scientists Sponsorship Program by CACM |
No. CACM-2022-QNRC2-A01 |
| China Postdoctoral Science Foundation |
No. 2023M743146 |
| Zhejiang Chinese Medical University Scientific Research Project for Talent |
No. 2023RCZXZK47 |
| National Postdoctoral Research Program |
No. GZC20232373 |
| China-Japan Friendship Hospital Scientific Research Fund |
No. 2024-ZF-12 |
|
| Corresponding Author |
Xue-Cheng Zhang, MD, Department of Proctology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. zhangxuecheng@zryhyy.com.cn |
| Key Words |
Perianal abscess; Prevention; Obesity; Lipid metabolism profile; Case-control study; Mendelian randomization |
| Core Tip |
Our case-control study revealed that the risk of perianal abscesses (PAs) was significantly correlated with various obesity/metabolic markers, including higher body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio, glucose levels, uric acid levels, cholesterol levels, triglyceride levels, and low-density lipoprotein (LDL) cholesterol levels, as well as lower levels of high-density lipoprotein cholesterol. The mendelian randomization analysis further confirmed relationships between the PA risk and factors such as BMI, WHR, large and medium LDLs, and lipid ratios. These findings suggest that lipid levels, body fat distribution, and metabolic markers are crucial to the understanding of PA risk. |
| Publish Date |
2026-01-21 09:49 |
| Citation |
Ma HF, Qian JH, Chen YH, Wang Y, Wang YM, Li JN, Zhou ZY, Ma JX, Zhang XC. Targeting obesity and lipid metabolism profiles to prevent perianal abscesses: A case-control study and Mendelian randomization analysis. World J Gastrointest Surg 2026; 18(1): 113855 |
| URL |
https://www.wjgnet.com/1948-9366/full/v18/i1/113855.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v18.i1.113855 |
