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Articles Published Processes
12/19/2025 8:32:40 AM | Browse: 5 | Download: 4
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Received |
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2025-09-05 09:04 |
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Peer-Review Started |
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2025-09-05 09:04 |
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First Decision by Editorial Office Director |
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2025-09-23 08:34 |
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Return for Revision |
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2025-09-23 08:34 |
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Revised |
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2025-10-01 23:14 |
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Publication Fee Transferred |
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2025-10-03 14:04 |
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Second Decision by Editor |
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2025-10-24 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-24 06:51 |
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Articles in Press |
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2025-10-24 06:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-08 02:37 |
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Publish the Manuscript Online |
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2025-12-19 08:32 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Observational Study |
| Article Title |
Synthetic messenger RNA vaccines and transcriptomic dysregulation: Evidence from new-onset adverse events and cancers post-vaccination
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Natalia Lidmar Von Ranke, Wei Zhang, Philipp Anokhin, Nicolas Hulscher, Kevin McKernan, Peter Mccullough and John Catanzaro |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
John Catanzaro, MD, PhD, Development of R and D, Neo7Bioscience, 2500 Summer Lee Dr, Rockwall, Dallas, TX 75032, United States. john.catanzaro@neo7bioscience.com |
| Key Words |
Coronavirus disease; Vaccine; RNA-seq; Immune dysregulation; Cancer |
| Core Tip |
This study demonstrates that individuals experiencing new-onset adverse events or cancer after messenger RNA (mRNA) coronavirus disease 2019 vaccination exhibit widespread transcriptomic dysregulation. Bulk RNA sequencing revealed hallmarks of mitochondrial dysfunction, systemic inflammation, proteasome and ribosomal stress, and nonsense-mediated decay, with additional genomic instability and epigenetic reprogramming in cancer patients. Notably, myelocytomatosis oncogene activation and heightened immune signaling via toll-like receptors and type I interferons were observed. These findings highlight shared and distinct molecular signatures, underscoring the need for further investigation into long-term mRNA vaccine safety and host variability. |
| Publish Date |
2025-12-19 08:32 |
| Citation |
Von Ranke NL, Zhang W, Anokhin P, Hulscher N, McKernan K, Mccullough P, Catanzaro J. Synthetic messenger RNA vaccines and transcriptomic dysregulation: Evidence from new-onset adverse events and cancers post-vaccination. World J Exp Med 2025; 15(4): 113869 |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i4/113869.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i4.113869 |
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