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Articles Published Processes
2/9/2015 5:58:00 PM | Browse: 1173 | Download: 1602
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Received |
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2014-05-19 20:19 |
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Peer-Review Started |
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2014-05-20 15:51 |
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To Make the First Decision |
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2014-06-27 17:36 |
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Return for Revision |
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2014-07-07 10:03 |
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Revised |
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2014-08-06 00:00 |
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Second Decision |
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2014-10-15 12:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-15 17:42 |
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Articles in Press |
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2014-10-15 17:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-10-20 18:31 |
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Typeset the Manuscript |
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2015-01-23 19:27 |
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Publish the Manuscript Online |
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2015-02-09 17:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Autobiography |
| Article Title |
Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong-Hong Lu, Xiao-Yun Guo, Shan-Yu Qin, Wei Luo, Xiao-Li Huang, Mei Chen, Jia-Xu Wang, Shi-Jia Ma, Xian-Wen Yang and Hai-Xing Jiang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81260083 |
| Guangxi Natural Science Foundation of China |
2014jjAA40237 |
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| Corresponding Author |
Hai-Xing Jiang, PhD, Professor, Department of Gastroenterology, The First Affiliated Hospital, Guangxi Medical University, No. 22, Shuang Yong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. jihaxi@163.com |
| Key Words |
T helper 22 cells; T helper 17 cells; T helper 1 cells; Interleukin-22; Hepatic fibrosis |
| Core Tip |
T helper (Th)-22 cells are involved in tissue inflammation and immunity. The presence of Th22 cells and the role of interleukin (IL)-22 in hepatic fibrosis have seldom been reported. The present study examined the frequency of Th22 cells, investigated the expression of IL-22, and determined the effects of recombinant IL-22 on hepatic fibrosis in mice. The aim of this preliminary study was to determine the presence of Th22 cells and the functional characteristics of IL-22 in hepatic fibrosis. The frequency of Th22 cells was elevated in mice with hepatic fibrosis. Recombinant IL-22 ameliorated liver fibrogenesis via attenuation of hepatic stellate cell activation and down-regulation of inflammatory cytokines. |
| Publish Date |
2015-02-09 17:58 |
| Citation |
Lu DH, Guo XY, Qin SY, Luo W, Huang XL, Chen M, Wang JX, Ma SJ, Yang XW, Jiang HX. Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines. World J Gastroenterol 2015; 21(5): 1531-1545 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i5/1531.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i5.1531 |
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