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2/3/2026 6:28:09 AM | Browse: 2 | Download: 14
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 113922
Country China
Received
2025-10-14 09:10
Peer-Review Started
2025-10-14 09:10
First Decision by Editorial Office Director
2025-10-24 06:33
Return for Revision
2025-10-24 06:33
Revised
2025-11-21 06:36
Publication Fee Transferred
2025-11-24 11:53
Second Decision by Editor
2025-12-18 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-12-18 07:55
Articles in Press
2025-12-18 07:55
Edit the Manuscript by Language Editor
2025-12-24 04:25
Typeset the Manuscript
2026-01-27 00:35
Publish the Manuscript Online
2026-02-03 06:28
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Clinical Trials Study
Article Title Clinical efficacy of Fuzheng Jiedu Xiaoyong granules in advanced colorectal cancer (spleen deficiency and stasis toxin syndrome)
Manuscript Source Unsolicited Manuscript
All Author List Hai-Yun Qin, Zheng Li, Pei-Wei Cong, Dan Mi, Feng-Zhen Li, Xin Hu and Guo-Xin Li
ORCID
Author(s) ORCID Number
Hai-Yun Qin http://orcid.org/0009-0009-4847-7186
Zheng Li http://orcid.org/0000-0002-2006-7531
Guo-Xin Li http://orcid.org/0009-0007-4190-5358
Funding Agency and Grant Number
Corresponding Author Guo-Xin Li, Chief Physician, PhD, Professor, Guoyi Hall, The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 60, Huanghe North Street, Huanggu District, Shenyang City, Liaoning Province, China, Shenyang 110034, Liaoning Province, China. syyljdlgx024@126.com
Key Words Advanced colorectal cancer; Fuzheng Jiedu Xiaoyong granules; First-line therapy; Randomized controlled trial; Immune function
Core Tip The combination of Fuzheng Jiedu Xiaoyong granules (FZJDXYG) with first-line therapy for advanced colorectal cancer (CRC) demonstrates significant clinical efficacy with minimal adverse effects. It has effectively modulated immune dysfunction and improved patients’ quality of life. A parallel, randomized, controlled trial confirmed the significant efficacy and high safety of FZJDXYG in treating advanced CRC patients. Moreover, FZJDXYG significantly increased the CD4+ T cell ratio, reduced the CD8+ T cell ratio, and elevated the CD4+/CD8+ ratio in patients, with significant differences both before and after treatment, as well as between the treatment and control group.
Publish Date 2026-02-03 06:28
Citation

Qin HY, Li Z, Cong PW, Mi D, Li FZ, Hu X, Li GX. Clinical efficacy of Fuzheng Jiedu Xiaoyong granules in advanced colorectal cancer (spleen deficiency and stasis toxin syndrome). World J Gastrointest Oncol 2026; 18(2): 113922

URL https://www.wjgnet.com/1948-5204/full/v18/i2/113922.htm
DOI https://dx.doi.org/10.4251/wjgo.v18.i2.113922
Full Article (PDF) WJGO-18-113922-with-cover.pdf
CONSORT 2010 Statement 113922-CONSORT-2010-statement.pdf
Manuscript File 113922_Auto_Edited_105321.docx
Answering Reviewers 113922-answering-reviewers.pdf
Audio Core Tip 113922-audio.mp3
Biostatistics Review Certificate 113922-biostatistics-statement.pdf
Clinical Trial Registration Statement 113922-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form 113922-conflict-of-interest-statement.pdf
Copyright License Agreement 113922-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 113922-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 113922-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 113922-non-native-speakers.pdf
Peer-review Report 113922-peer-reviews.pdf
Scientific Misconduct Check 113922-scientific-misconduct-check.png
Scientific Editor Work List 113922-scientific-editor-work-list.pdf
CrossCheck Report 113922-crosscheck-report.pdf