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Articles Published Processes
12/25/2025 3:52:10 AM | Browse: 2 | Download: 1
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Received |
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2025-09-07 07:21 |
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Peer-Review Started |
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2025-09-07 07:21 |
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First Decision by Editorial Office Director |
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2025-09-30 08:01 |
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Return for Revision |
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2025-09-30 08:01 |
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Revised |
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2025-10-25 19:19 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-02 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-03 03:49 |
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Articles in Press |
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2025-12-03 03:49 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-17 08:57 |
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Publish the Manuscript Online |
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2025-12-25 03:52 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Exercise with induced pluripotent stem cells enhances Wnt1-Lmx1a signaling and dopaminergic neurogenesis to alleviate Parkinsonian symptoms
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Aya Arafat, Soliman Mehawed Abdellatif Soliman, Thoraya A Farghaly and Noura A A Ebrahim |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Noura A A Ebrahim, Department of Oncologic Pathology, National Cancer Institute, Cairo University, 1st Kasr Alainy Street, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com |
| Key Words |
Parkinson’s disease; Induced pluripotent stem cells; Exercise; Wnt1-Lmx1a signaling; Dopaminergic neurogenesis; Biomaterials; Neuroregeneration; Stem cell transplantation |
| Core Tip |
This letter builds on Jiang et al’s recent findings that voluntary exercise enhances the therapeutic impact of induced pluripotent stem cell transplantation in Parkinson’s disease by activating the Wnt1-Lmx1a pathway. We highlight exercise as a molecular modulator that fosters a neurogenic milieu, recommend examining additional developmental signals (sonic hedgehog, fibroblast growth factor 8, bone morphogenetic protein), and suggest biomaterial-based strategies to support graft survival and integration. We also stress the need to optimize exercise regimens in relation to transplantation, framing these insights within a translational strategy for advancing regenerative therapies in Parkinson’s disease. |
| Publish Date |
2025-12-25 03:52 |
| Citation |
Arafat A, Soliman SMA, Farghaly TA, Ebrahim NAA. Exercise with induced pluripotent stem cells enhances Wnt1-Lmx1a signaling and dopaminergic neurogenesis to alleviate Parkinsonian symptoms. World J Stem Cells 2025; 17(12): 113924 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i12/113924.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i12.113924 |
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