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Articles Published Processes
1/16/2026 11:30:28 AM | Browse: 1 | Download: 0
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Received |
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2025-09-08 03:47 |
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Peer-Review Started |
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2025-09-08 03:48 |
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First Decision by Editorial Office Director |
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2025-09-20 02:36 |
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Return for Revision |
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2025-09-20 02:36 |
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Revised |
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2025-10-01 15:12 |
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Publication Fee Transferred |
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2025-10-09 05:19 |
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Second Decision by Editor |
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2025-11-25 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-25 06:38 |
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Articles in Press |
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2025-11-25 06:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-12 09:52 |
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Publish the Manuscript Online |
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2026-01-16 11:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
Targeting Jun N-terminal kinase phosphorylation: A human-derived hepatoprotective peptide human liver transplantation peptide 1 attenuates hepatic ischemia-reperfusion injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Wen Xie, Qun Bao, Zi-Xuan Chen, Xiang-Min Zhang, Xi-Yu Liu, Rui Wang, Yue-Song Cai and Peng Sun |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82070634 |
| National Key Research and Development Program of China |
2021YFC2701900 |
| Natural Science Foundation of Shanghai Municipality |
23ZR1458200 |
| Shanghai Sixth People’s Hospital Medical Group |
ly202401 |
| Shanghai Jiao Tong University Cross Disciplinary Translational Foundation |
YG2022QN117 |
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| Corresponding Author |
Peng Sun, Department of General Surgery, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Shanghai 200336, China. surgeonpeng@foxmail.com |
| Key Words |
Hepatic ischemia-reperfusion injury; Peptidomics; Peptide; Apoptosis; Jun N-terminal kinase phosphorylation |
| Core Tip |
This study pioneers the discovery of a novel endogenous peptide, human liver transplantation peptide 1, directly from clinical human liver transplant samples using peptidomics. We demonstrate that human liver transplantation peptide 1 confers significant protection against hepatic ischemia-reperfusion injury by specifically inhibiting Jun N-terminal kinase phosphorylation and subsequent hepatocyte apoptosis. This work is the first to identify a therapeutically promising peptide of human origin with this mechanism for hepatic ischemia-reperfusion injury, offering a highly translatable and innovative strategy to improve outcomes in liver transplantation and other ischemic liver conditions. |
| Publish Date |
2026-01-16 11:30 |
| Citation |
Xie HW, Bao Q, Chen ZX, Zhang XM, Liu XY, Wang R, Cai YS, Sun P. Targeting Jun N-terminal kinase phosphorylation: A human-derived hepatoprotective peptide human liver transplantation peptide 1 attenuates hepatic ischemia-reperfusion injury. World J Gastroenterol 2026; 32(3): 113935 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i3/113935.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i3.113935 |
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