8/5/2026 7:53:17 AM | Browse: 1 | Download: 0
| Publication Name | World Journal of Diabetes |
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| Manuscript ID | 113938 |
| Country | China |
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| ISSN | 1948-9358 (online) |
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| Open Access | Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright | ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Toxicology | ||||||||||||||||
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| Manuscript Type | Basic Study | ||||||||||||||||
| Article Title | Study on the role of CCM3 in neurological damage in lead exposure of diabetes | ||||||||||||||||
| Manuscript Source | Unsolicited Manuscript | ||||||||||||||||
| All Author List | Xu Liang, Liu-Xue Yang, Tao Tao, Wen-Jia Ding, Xin-Yi Tang, Zhi-Bin Shang, Hang Zhou, Yun He and Yi Sun | ||||||||||||||||
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| Corresponding Author | Yi Sun, Department of Toxicology, Guilin Medical University, No. 1 Zhiyuan Road, Lingui District, Guilin 541199, Guangxi Zhuang Autonomous Region, China. sunyide163@163.com | ||||||||||||||||
| Key Words | CCM3; Lead; Diabetes; PI3K-AKT; Ferroptosis | ||||||||||||||||
| Core Tip | Using a diabetic, CCM3-deficient mouse model with lead exposure, this study demonstrates that lead exposure, diabetes, and CCM3 loss synergistically increase blood glucose and lead levels, resulting in neural injury that precedes vascular damage. Lead triggers early neural impairment by inhibiting the PI3K-AKT signaling pathway and promoting ferroptosis, a mechanism distinct from glucose-related effects. Epidemiological analyses further confirm that interactions among urinary lead levels, blood glucose, and the CCM3 single-nucleoyide polymorphisms rs6784267 significantly influence the neurotransmitter metabolites vanillylmandelic acid and homovanillic acid, consistent with animal findings. Collectively, these results provide a scientific basis for the prevention early neural damage involving environmental, metabolic, and genetic factors. | ||||||||||||||||
| Publish Date | 2026-08-05 07:53 | ||||||||||||||||
| Citation |
Liang X, Yang LX, Tao T, Ding WJ, Tang XY, Shang ZB, Zhou H, He Y, Sun Y. Study on the role of CCM3 in neurological damage in lead exposure of diabetes. World J Diabetes 2026; 17(8): 113938 |
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| URL | https://www.wjgnet.com/1948-9358/full/v17/i8/113938.htm | ||||||||||||||||
| DOI | https://doi.org/10.4239/wjd.113938 |
| Full Article (PDF) | WJD-17-113938-with-cover.pdf |
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| The ARRIVE Guidelines | 113938-The-ARRIVE-Guidelines.pdf |
| Manuscript File | 113938_Auto_Edited_013513.docx |
| Answering Reviewers | 113938-answering-reviewers.pdf |
| Audio Core Tip | 113938-audio.mp3 |
| Biostatistics Review Certificate | 113938-biostatistics-statement.pdf |
| Conflict-of-Interest Disclosure Form | 113938-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 113938-copyright-assignment.pdf |
| Institutional Animal Care and Use Committee Approval Form or Document | 113938-institutional-animal-care-and-use-committee-statement.pdf |
| Institutional Review Board Approval Form or Document | 113938-institutional-review-board-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 113938-non-native-speakers.pdf |
| Peer-review Report | 113938-peer-reviews.pdf |
| Scientific Misconduct Check | 113938-scientific-misconduct-check.png |
| Scientific Editor Work List | 113938-scientific-editor-work-list.pdf |
| CrossCheck Report | 113938-crosscheck-report.pdf |