| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Lactate metabolism-driven tumor heterogeneity and molecular signatures in intrahepatic cholangiocarcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
An-Ke Wu, Jun-Yi Li, Kai Zhang, Martin Meng, Xue Wang, Yue Liu, Peng Xie, Wei-Qi Rong, Fan Wu, Hong-Guang Wang, Xuan Meng and Jian-Xiong Wu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82272963 |
| Natural Science Foundation of Beijing Municipal |
No. 4222058 |
| Shenzhen Major Scientific and Technological Project |
No. KJZD20230923114615031 |
| National Natural Science Foundation of China |
No. 82473496 |
|
| Corresponding Author |
Jian-Xiong Wu, MD, Professor, Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan South Lane, Beijing 100021, China. dr_wujx@163.com |
| Key Words |
Intrahepatic cholangiocarcinoma; Lactate metabolism; Single-cell RNA sequencing; Metabolic heterogeneity; Tumor microenvironment |
| Core Tip |
This study integrates single-cell and bulk transcriptomic data with machine learning to uncover lactate metabolism-driven heterogeneity in intrahepatic cholangiocarcinoma (ICC). Twelve lactate metabolism-related genes were identified as prognostic biomarkers, and functional validation of CYC1 revealed its role in promoting tumor invasion. These findings provide new insights into ICC progression and offer promising targets for diagnosis and therapy. |
| Publish Date |
2026-02-06 08:53 |
| Citation |
Wu AK, Li JY, Zhang K, Meng M, Wang X, Liu Y, Xie P, Rong WQ, Wu F, Wang HG, Meng X, Wu JX. Lactate metabolism-driven tumor heterogeneity and molecular signatures in intrahepatic cholangiocarcinoma. World J Gastroenterol 2026; 32(7): 113973 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i7/113973.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i7.113973 |
