| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Exercise-responsive skeletal muscle genes mechanistically linked to metabolic dysfunction-associated steatotic liver disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Hui Zhang, Kang Chen, Xiao-Min Zhu, Huan Zhou, Jia-Mi Jiang, Yu-Qing Zou, Ke-Rong Liu, Le Zhang and Yun Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Wuxi Science and Technology Development Fund |
No. K20241001 |
| Wuxi Science and Technology Development Fund |
No. Y20232026 |
| Jiangsu Medical Association Pediatric Medicine Phase II Scientific Research Special Fund Project |
No. SYH-32034-0106 (2024010) |
| Top Talent Support Program for Young and Middle-Aged People of Wuxi Health Committee |
No. HB2023091 |
| Top Talent Support Program for Young and Middle-Aged People of Wuxi Health Committee |
No. BJ2023090 |
| Medical Key Discipline Program of Wuxi Health Commission |
No. ZDXK2021007 |
|
| Corresponding Author |
Yun Li, PhD, Research Assistant Professor, Department of Pediatric Laboratory, Affiliated Children’s Hospital of Jiangnan University, Wuxi Children’s Hospital, Wuxi Key Laboratory of Genetic and Metabolic Diseases in Children, No. 299 Qingyang Road, Liangxi District, Wuxi 214023, Jiangsu Province, China. yunli_med@jiangnan.edu.cn |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Myokines; Weighted gene co-expression network analysis; LAMA4; PECAM1; PXDN; THBS4 |
| Core Tip |
This study identified four exercise-responsive skeletal muscle-expressed genes (LAMA4, PECAM1, PXDN and THBS4), which were mechanistically linked to metabolic dysfunction-associated steatotic liver disease (MASLD). These genes may serve as myokine-like candidates, shedding light on the molecular pathways by which exercise mediates metabolic adaptation in MASLD. The findings provided novel insights into the pathophysiology of MASLD and suggested these biomarkers as promising candidates for precision diagnostics and therapeutic interventions. |
| Publish Date |
2026-03-27 06:07 |
| Citation |
Zhang JH, Chen K, Zhu XM, Zhou H, Jiang JM, Zou YQ, Liu KR, Zhang L, Li Y. Exercise-responsive skeletal muscle genes mechanistically linked to metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(13): 113985 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i13/113985.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i13.113985 |
