| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Neuroprotective potential of a plant-based intervention in diabetic neuropathy: Biochemical and behavioral insights from a streptozotocin-induced rat model
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mohd Adnan Kausar, Kehkashan Parveen, Sadaf Anwar, Yusuf Saleem Khan, Ayman A Saleh, Mai Ali Abdelfattah Ahmed, Waseem Ahmad Siddiqui and Suhel Parvez |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Deanship at University of Ha'il Saudi Arabia |
RG-24 082 |
|
| Corresponding Author |
Mohd Adnan Kausar, PhD, Professor, Department of Biochemistry, College of Medicine, University of Ha’il, University City-Hail, Al Khitah Street, Hail 53962, Saudi Arabia. ma.kausar@uoh.edu.sa |
| Key Words |
Diabetes; Polyherbal extract; Oxidative stress; Inflammation; Neurotrophic factors |
| Core Tip |
Diabetic neuropathy represents the primary complication of diabetes, characterized by oxidative stress, inflammation, and impaired neurotrophic signaling. In streptozotocin-induced diabetic rats, a polyherbal extract derived from Curcuma longa, Myristica fragrans, and Citrullus colocynthis significantly enhanced metabolic parameters, improved lipid profile and promoted antioxidant defense, and neurobehavioral outcomes. It reversed behavioral impairments and histological damage by lowering hyperglycemia, raising insulin levels, and reducing neuroinflammation and oxidative stress. These findings demonstrate the neuroprotective qualities of polyherbal extract and encourage more research into plant-based remedies for diabetic neuropathy. |
| Publish Date |
2026-02-06 08:43 |
| Citation |
Kausar MA, Parveen K, Anwar S, Khan YS, Saleh AA, Ahmed MAA, Siddiqui WA, Parvez S. Neuroprotective potential of a plant-based intervention in diabetic neuropathy: Biochemical and behavioral insights from a streptozotocin-induced rat model. World J Diabetes 2026; 17(2): 113992 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i2/113992.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i2.113992 |
