BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
2/14/2026 6:34:08 AM | Browse: 0 | Download: 0
 |
Received |
|
2025-09-10 08:04 |
|
Peer-Review Started |
|
2025-09-10 08:08 |
|
First Decision by Editorial Office Director |
|
2025-09-28 09:29 |
|
Return for Revision |
|
2025-09-28 09:29 |
|
Revised |
|
2025-10-20 15:32 |
|
Publication Fee Transferred |
|
2025-10-23 09:49 |
|
Second Decision by Editor |
|
2026-01-13 02:38 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-01-14 09:23 |
|
Articles in Press |
|
2026-01-14 09:23 |
|
Edit the Manuscript by Language Editor |
|
2026-01-19 17:24 |
|
Typeset the Manuscript |
|
2026-02-04 02:28 |
|
Publish the Manuscript Online |
|
2026-02-14 06:34 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Basic Study |
| Article Title |
Epiregulin enhances periodontal tissue regeneration by promoting bone marrow mesenchymal stem cell functions under inflammatory niches
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying-Chu Zhao, Guo-Yue Li, Si Chen, Yi-Lin Wang, Jing-Yi Feng and Yu Cao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81670948 |
|
| Corresponding Author |
Yu Cao, PhD, Professor, Vice Director, Department of Wangfujing General School of Stomatology, Capital Medical University School of Stomatology, No. 11 Pewter Lane, Dongcheng District, Beijing 100010, China. caoyu_bj@163.com |
| Key Words |
Inflammatory conditions; Bone marrow mesenchymal stem cells; Epiregulin; Periodontal tissue regeneration; Epiregulin-epidermal growth factor receptor-extracellular signal-regulated kinase 1/2 pathway; Inflammatory niche |
| Core Tip |
Enhancing the function of the repaired stem cells in the inflammatory niche is crucial for periodontal tissue regeneration. This study revealed that epiregulin (EREG) enhanced the migration, chemotaxis, and osteogenesis of mouse bone marrow stem cells under inflammatory conditions. Furthermore, EREG activates the extracellular signal-regulated kinase 1/2 pathway by binding to epidermal growth factor receptor. Disruption of this pathway affected the function of mouse bone marrow stem cells. Finally, the local injection of EREG promoted periodontal tissue regeneration. These findings suggest a novel therapeutic strategy for the treatment of periodontitis. |
| Publish Date |
2026-02-14 06:34 |
| Citation |
Zhao YC, Li GY, Chen S, Wang YL, Feng JY, Cao Y. Epiregulin enhances periodontal tissue regeneration by promoting bone marrow mesenchymal stem cell functions under inflammatory niches. World J Stem Cells 2026; 18(2): 114032 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i2/114032.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i2.114032 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
