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Articles Published Processes
2/28/2026 8:32:56 AM | Browse: 3 | Download: 15
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Received |
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2025-09-11 07:52 |
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Peer-Review Started |
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2025-09-11 07:52 |
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First Decision by Editorial Office Director |
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2025-10-10 03:18 |
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Return for Revision |
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2025-10-10 03:18 |
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Revised |
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2025-10-21 09:20 |
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Publication Fee Transferred |
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2025-10-25 10:25 |
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Second Decision by Editor |
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2025-12-02 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-02 06:30 |
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Articles in Press |
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2025-12-02 06:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-13 03:57 |
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Publish the Manuscript Online |
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2026-02-28 08:32 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Observational Study |
| Article Title |
Clinical symptom improvement following modified electroconvulsive therapy is associated with modulation of peripheral inflammatory markers in schizophrenia
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lu Hou, Ru Chen, Cheng-Bing Huang, Wen-Jie Shi and Li-Li Wu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wen-Jie Shi, Academic Fellow, Chief Physician, Department of Psychiatry, Huai’an Third People’s Hospital, No. 272 Huaihai West Road, Huai’an 223001, Jiangsu Province, China. shiwenjie197948@126.com |
| Key Words |
Modified electroconvulsive therapy; Schizophrenia; Immunoinflammation; Monocyte-to-lymphocyte ratio; Positive and Negative Syndrome Scale score reduction rate |
| Core Tip |
This study demonstrates that modified electroconvulsive therapy significantly improves clinical symptoms and reduces peripheral inflammatory markers - including monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio, and systemic immune-inflammatory indices - in patients with schizophrenia. Reductions in MLR were strongly correlated with clinical improvement and served as a robust predictor of treatment response. Specifically, each 0.1-unit increase in ΔMLR was associated with a 57% higher likelihood of significant symptom improvement. These findings suggest an immunomodulatory mechanism of modified electroconvulsive therapy and support the use of MLR as a potential biomarker for predicting treatment efficacy. |
| Publish Date |
2026-02-28 08:32 |
| Citation |
Hou L, Chen R, Huang CB, Shi WJ, Wu LL. Clinical symptom improvement following modified electroconvulsive therapy is associated with modulation of peripheral inflammatory markers in schizophrenia. World J Psychiatry 2026; 16(3): 114036 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i3/114036.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i3.114036 |
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