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Articles Published Processes
2/28/2026 8:32:56 AM | Browse: 147 | Download: 591
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Received |
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2025-09-11 07:52 |
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Peer-Review Started |
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2025-09-11 07:52 |
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First Decision by Editorial Office Director |
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2025-10-10 03:18 |
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Return for Revision |
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2025-10-10 03:18 |
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Revised |
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2025-10-21 09:20 |
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Publication Fee Transferred |
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2025-10-25 10:25 |
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Second Decision by Editor |
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2025-12-02 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-02 06:30 |
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Articles in Press |
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2025-12-02 06:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-13 03:57 |
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Publish the Manuscript Online |
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2026-02-28 08:32 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Observational Study |
| Article Title |
Clinical symptom improvement following modified electroconvulsive therapy is associated with modulation of peripheral inflammatory markers in schizophrenia
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lu Hou, Ru Chen, Cheng-Bing Huang, Wen-Jie Shi and Li-Li Wu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wen-Jie Shi, Academic Fellow, Chief Physician, Department of Psychiatry, Huai’an Third People’s Hospital, No. 272 Huaihai West Road, Huai’an 223001, Jiangsu Province, China. shiwenjie197948@126.com |
| Key Words |
Modified electroconvulsive therapy; Schizophrenia; Immunoinflammation; Monocyte-to-lymphocyte ratio; Positive and Negative Syndrome Scale score reduction rate |
| Core Tip |
This study demonstrates that modified electroconvulsive therapy significantly improves clinical symptoms and reduces peripheral inflammatory markers - including monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio, and systemic immune-inflammatory indices - in patients with schizophrenia. Reductions in MLR were strongly correlated with clinical improvement and served as a robust predictor of treatment response. Specifically, each 0.1-unit increase in ΔMLR was associated with a 57% higher likelihood of significant symptom improvement. These findings suggest an immunomodulatory mechanism of modified electroconvulsive therapy and support the use of MLR as a potential biomarker for predicting treatment efficacy. |
| Publish Date |
2026-02-28 08:32 |
| Citation |
Hou L, Chen R, Huang CB, Shi WJ, Wu LL. Clinical symptom improvement following modified electroconvulsive therapy is associated with modulation of peripheral inflammatory markers in schizophrenia. World J Psychiatry 2026; 16(3): 114036
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| URL |
https://www.wjgnet.com/2220-3206/full/v16/i3/114036.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i3.114036 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
