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Articles Published Processes
1/12/2026 10:07:40 AM | Browse: 1 | Download: 11
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Received |
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2025-09-10 08:19 |
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Peer-Review Started |
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2025-09-10 08:21 |
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First Decision by Editorial Office Director |
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2025-09-29 09:04 |
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Return for Revision |
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2025-09-29 10:35 |
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Revised |
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2025-10-21 08:01 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-24 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-24 07:18 |
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Articles in Press |
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2025-11-24 07:18 |
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Edit the Manuscript by Language Editor |
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2025-11-25 10:32 |
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Typeset the Manuscript |
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2026-01-04 02:07 |
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Publish the Manuscript Online |
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2026-01-12 10:07 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Tight junction proteins: Gatekeepers turned facilitators in the pathogenesis of gastric adenocarcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shobha Selvam and Balasubramaniyan Vairappan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Balasubramaniyan Vairappan, Additional Professor, PhD, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantari Nagar, Pondicherry 605006, India. balasubramaniyan.v@jipmer.edu.in |
| Key Words |
Claudins; Gastric cancer; Infection and inflammation; Occludin and zonula occludens; Tight junction |
| Core Tip |
Tight junction (TJ) proteins play a pivotal role in preserving the integrity of the gastric epithelial barrier. Their dysregulation represents a critical early event linking chronic inflammation to gastric carcinogenesis. Inflammatory mediators induce TJ remodeling, thereby increasing mucosal permeability and promoting tumor initiation and progression. Emerging therapeutic strategies targeting TJ proteins either by pharmacologically restoring barrier integrity or modulating aberrant TJ signaling offer promising avenues to suppress inflammation, inhibit tumor growth and metastasis, and ultimately improve clinical outcomes in gastric cancer patients. |
| Publish Date |
2026-01-12 10:07 |
| Citation |
Selvam S, Vairappan B. Tight junction proteins: Gatekeepers turned facilitators in the pathogenesis of gastric adenocarcinoma. World J Gastrointest Oncol 2026; 18(1): 114040 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i1/114040.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i1.114040 |
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