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Articles Published Processes
5/11/2026 9:00:23 AM | Browse: 6 | Download: 10
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Received |
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2025-09-10 06:04 |
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Peer-Review Started |
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2025-09-15 00:27 |
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First Decision by Editorial Office Director |
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2025-10-27 09:16 |
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Return for Revision |
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2025-10-27 09:16 |
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Revised |
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2026-03-10 19:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-26 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-26 03:53 |
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Articles in Press |
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2026-03-26 03:53 |
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Edit the Manuscript by Language Editor |
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2026-03-31 04:40 |
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Typeset the Manuscript |
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2026-04-28 09:42 |
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Publish the Manuscript Online |
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2026-05-11 09:00 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
From lipodystrophy to subcutaneous insulin depots: Overlooked mechanisms of glycemic variability in patients with diabetes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nhi Thi Y Nguyen, Hau Phuc Tran, Thang Viet Luong, Dat Xuan Nguyen, Duong Hung Tran, Phuong Ho Thi Hoai, Meng-Chi Lee and Hai Nguyen Ngoc Dang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hai Nguyen Ngoc Dang, Menzies Institute for Medical Research, University of Tasmania, 1/17 Liverpool Street, Hobart 7000, Tasmania, Australia. ngochai123dc@gmail.com |
| Key Words |
Insulin depot; Lipohypertrophy; Lipodystrophy; Insulin absorption; Injection technique; Ultrasound; Diabetes |
| Core Tip |
Lipohypertrophy is a common but often overlooked cause of unstable insulin activity. Tissue hypertrophy and fibrosis at injection sites can create insulin depot behavior, leading to delayed and unpredictable absorption with both hyperglycemia and late hypoglycemia. A practical management pathway combines routine injection-site inspection with palpation (and ultrasound when needed), structured rotation and technique education, and close monitoring with individualized dose adjustment when patients are switched away from affected areas. Embedding injection-site care into routine insulin titration can reduce avoidable glycemic variability and improve insulin safety. |
| Publish Date |
2026-05-11 09:00 |
| Citation |
Nguyen NTY, Tran HP, Luong TV, Nguyen DX, Tran DH, Hoai PHT, Lee MC, Dang HNN. From lipodystrophy to subcutaneous insulin depots: Overlooked mechanisms of glycemic variability in patients with diabetes. World J Diabetes 2026; 17(5): 114042 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i5/114042.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i5.114042 |
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