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Publication Name World Journal of Hepatology
Manuscript ID 114045
Country Portugal
Received
2025-09-11 07:53
Peer-Review Started
2025-09-11 07:54
First Decision by Editorial Office Director
2025-09-23 08:21
Return for Revision
2025-09-23 08:21
Revised
2025-10-09 09:31
Publication Fee Transferred
Second Decision by Editor
2025-11-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-11-25 11:52
Articles in Press
2025-11-25 11:52
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-13 06:37
Publish the Manuscript Online
2026-01-27 10:12
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Not always autoimmune hepatitis: Hepatic steatosis is associated with autoantibodies positivity in patients with hepatocellular dysfunction
Manuscript Source Unsolicited Manuscript
All Author List Ana Isabel Ferreira, Mariana Costa Azevedo, Vitor Macedo Silva, Sofia Xavier, Joana Magalhães and José Cotter
ORCID
Author(s) ORCID Number
Ana Isabel Ferreira http://orcid.org/0000-0003-0076-840X
Vitor Macedo Silva http://orcid.org/0000-0001-8001-9067
Sofia Xavier http://orcid.org/0000-0001-6214-0584
Joana Magalhães http://orcid.org/0000-0003-4176-7120
José Cotter http://orcid.org/0000-0002-2921-0648
Funding Agency and Grant Number
Corresponding Author Ana Isabel Ferreira, MD, Gastroenterology Department, Unidade Local de Saúde do Alto Ave, R. dos Cutileiros 114, Creixomil, Guimaraes 4835-044, Portugal. ai.voferreira@gmail.com
Key Words Autoimmune hepatitis; Metabolic dysfunction-associated steatotic liver disease; Autoantibodies; Liver biopsy; Controlled attenuation parameter
Core Tip This retrospective study included 81 consecutive adult patients with liver dysfunction and positive autoantibodies undergoing liver biopsy. Autoimmune hepatitis was not confirmed in 47% of patients. In patients with anti-nuclear antibodies positivity, male gender and higher controlled attenuation parameter values emerged as independent predictive factors associated with non-confirmed diagnosis of autoimmune hepatitis. These findings generate a valuable hypothesis that may inform future updates to clinical decision algorithms, particularly considering the rising prevalence of metabolic dysfunction-associated steatotic liver disease.
Publish Date 2026-01-27 10:12
Citation

Ferreira AI, Costa Azevedo M, Macedo Silva V, Xavier S, Magalhães J, Cotter J. Not always autoimmune hepatitis: Hepatic steatosis is associated with autoantibodies positivity in patients with hepatocellular dysfunction. World J Hepatol 2026; 18(1): 114045

URL https://www.wjgnet.com/1948-5182/full/v18/i1/114045.htm
DOI https://dx.doi.org/10.4254/wjh.v18.i1.114045
Full Article (PDF) WJH-18-114045-with-cover.pdf
STROBE Statement 114045-STROBE-statement.pdf
Manuscript File 114045_Auto_Edited_071856.docx
Answering Reviewers 114045-answering-reviewers.pdf
Audio Core Tip 114045-audio.mp3
Biostatistics Review Certificate 114045-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 114045-conflict-of-interest-statement.pdf
Copyright License Agreement 114045-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 114045-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 114045-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 114045-non-native-speakers.pdf
Supplementary Material 114045-supplementary-material.pdf
Peer-review Report 114045-peer-reviews.pdf
Scientific Misconduct Check 114045-scientific-misconduct-check.png
Scientific Editor Work List 114045-scientific-editor-work-list.pdf
CrossCheck Report 114045-crosscheck-report.pdf