| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Clinical, pathological characteristics and long-term outcomes of hepatitis B virus related cirrhosis in pediatric observational study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bo-Kang Zhao, Yan Li, Yi-Yun Jiang, Mei-Ling Li, Yue Jiang, Li Zhu, Chao-Nan Guo, Shu-Hong Liu, Lin Chen, Li-Na Jiang, Jun-Qi Niu and Jing-Min Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key R&D Program of China |
2023YFC2308104 |
| Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support |
ZLRK202301 |
| National Natural Science Foundation of China |
92159305 |
|
| Corresponding Author |
Jing-Min Zhao, MD, PhD, Professor, Department of Pathology and Hepatology, The Fifth Medical Center of PLA General Hospital, No. 100 Xisihuan Middle Road, Fengtai District, Beijing 100039, China. jmzhao302@163.com |
| Key Words |
Pediatric; Hepatitis B virus; Liver cirrhosis; Clinical; Pathological |
| Core Tip |
Pediatric cirrhosis is mostly detected via physical examination with rare symptoms, whereas adults typically present with jaundice, hematochezia, and fatigue. Pediatric cirrhosis has a better prognosis than adult cases, with higher hepatitis B surface antigen seroclearance rates and potential rapid reversal in some instances, while adult cirrhosis generally carries a poor prognosis. Pediatric cirrhosis progresses more rapidly (even occurring in children < 3 years old), whereas adult cases follow a slower clinical course. Children with cirrhosis often have a history of liver dysfunction and frequently experience disease recurrence due to self-discontinuation of hepatoprotective/antiviral/traditional Chinese medicine treatments. |
| Publish Date |
2025-12-27 02:50 |
| Citation |
Zhao BK, Li Y, Jiang YY, Li ML, Jiang Y, Zhu L, Guo CN, Liu SH, Chen L, Jiang LN, Niu JQ, Zhao JM. Clinical, pathological characteristics and long-term outcomes of hepatitis B virus related cirrhosis in pediatric observational study. World J Gastroenterol 2025; 31(48): 114049 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i48/114049.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i48.114049 |
