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Articles Published Processes
3/6/2026 8:56:33 AM | Browse: 2 | Download: 14
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Received |
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2025-09-11 07:57 |
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Peer-Review Started |
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2025-09-11 07:57 |
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First Decision by Editorial Office Director |
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2025-09-23 08:45 |
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Return for Revision |
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2025-09-23 08:45 |
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Revised |
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2025-09-29 10:27 |
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Publication Fee Transferred |
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2025-10-02 09:47 |
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Second Decision by Editor |
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2025-11-24 02:49 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-24 09:57 |
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Articles in Press |
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2025-11-24 09:57 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-31 13:13 |
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Publish the Manuscript Online |
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2026-03-06 08:56 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Proteomic biomarkers for early diagnosis and prognosis in pediatric sepsis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guldana Sabitova, Zhalaliddin Makhammajanov, Marina Khvan, Pavel Tarlykov and Vitaliy Sazonov |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Nazarbayev University Faculty Development Grant for 2025-2027 |
No. 040225FD4716 |
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| Corresponding Author |
Vitaliy Sazonov, Assistant Professor, MD, Department of Surgery, School of Medicine, Nazarbayev University, Kabanbay Batyr 53, Astana Z05K4F4, Kazakhstan. vitaliy.sazonov@nu.edu.kz |
| Key Words |
Sepsis; Pediatric sepsis; Biomarkers; Proteomics; Multi-omics; Pediatric intensive care unit; Pediatrics |
| Core Tip |
Pediatric sepsis requires rapid and reliable "rule-in" tools upon presentation. This systematic review summarizes four pediatric proteomics studies and presents a practical pathway. Single markers, such as interleukin-27, serum amyloid A 1, soluble CD25, and leucine-rich alpha-2-glycoprotein 1, demonstrate high specificity for early diagnosis. The infant-focused combination of haptoglobin and thrombospondin 1 improves short-term risk stratification. We explain why age matters: Noting that immune maturation shifts effect sizes and may necessitate age-adjusted cut-points and neonatal-specific panels. We also map discovery platforms (aptamer/mass spectrometry) to rapid 3-5-plex immunoassays that are suitable for emergency department and pediatric intensive care unit use. Rather than offering pooled estimates, the systematic review provides translational guidance aimed at accelerating the deployment of clinically useful pediatric sepsis testing. |
| Publish Date |
2026-03-06 08:56 |
| Citation |
Sabitova G, Makhammajanov Z, Khvan M, Tarlykov P, Sazonov V. Proteomic biomarkers for early diagnosis and prognosis in pediatric sepsis. World J Clin Pediatr 2026; 15(1): 114054 |
| URL |
https://www.wjgnet.com/2219-2808/full/v15/i1/114054.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v15.i1.114054 |
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