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Articles Published Processes
1/12/2026 9:50:46 AM | Browse: 43 | Download: 201
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Received |
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2025-09-11 07:47 |
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Peer-Review Started |
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2025-09-11 07:47 |
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First Decision by Editorial Office Director |
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2025-10-22 09:06 |
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Return for Revision |
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2025-10-22 09:06 |
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Revised |
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2025-11-03 18:24 |
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Publication Fee Transferred |
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2025-11-04 01:48 |
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Second Decision by Editor |
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2025-11-18 01:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-18 09:19 |
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Articles in Press |
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2025-11-18 09:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-04 08:10 |
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Publish the Manuscript Online |
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2026-01-12 09:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Cedrol ameliorates ulcerative colitis via myeloid differentiation factor 2-mediated inflammation suppression, with barrier restoration and microbiota modulation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Qing Zhao, Yu Zhang, Yan Qin, Rui-Ya Zhang and Jun-Ping Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Provincial Key Cultivation Laboratory for Digestive Disease Research |
No. 2021SYS13 |
| Shanxi Province’s “Si Ge Yi Pi” Science and Technology Driven Medical Innovation Project |
No. 2021MX03 |
| Shanxi Provincial Basic Research Program |
No. 202403021222423 |
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| Corresponding Author |
Jun-Ping Wang, Chief Physician, MD, Professor, Department of Gastroenterology, Shanxi Provincial People’s Hospital Affiliated to Shanxi Medical University, No. 29 Shuangtasi Street, Taiyuan 030012, Shanxi Province, China. wangjp8396@sxmu.edu.cn |
| Key Words |
Cedrol; Ulcerative colitis; Toll-like receptor 4; Myeloid differentiation factor 2; Signaling pathways; Gut microbiota |
| Core Tip |
Therapeutics to treat ulcerative colitis (UC) must be effective and safe. The natural compound cedrol (CE) possesses anti-inflammatory and antioxidant properties. However, its therapeutic efficacy and mechanisms in UC remain unclear. We demonstrated that CE ameliorated dextran sulfate sodium-induced colitis in mice through multifaceted mechanisms: Attenuating inflammation; Promoting intestinal barrier repair; And restoring gut microbial homeostasis. Mechanistically, CE exerted its anti-inflammatory effects by functionally inhibiting the toll-like receptor 4/myeloid differentiation factor 2 complex, thereby inhibiting the activation of proinflammatory signaling pathways. These findings highlighted the potential of CE as a promising therapeutic agent for UC. |
| Publish Date |
2026-01-12 09:50 |
| Citation |
Zhao YQ, Zhang Y, Qin Y, Zhang RY, Wang JP. Cedrol ameliorates ulcerative colitis via myeloid differentiation factor 2-mediated inflammation suppression, with barrier restoration and microbiota modulation. World J Gastroenterol 2026; 32(2): 114057
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i2/114057.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i2.114057 |
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