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Publication Name World Journal of Cardiology
Manuscript ID 114077
Country Croatia
Received
2025-09-11 02:42
Peer-Review Started
2025-09-11 02:42
First Decision by Editorial Office Director
2025-10-13 08:14
Return for Revision
2025-10-13 08:14
Revised
2025-11-14 08:12
Publication Fee Transferred
2025-11-21 13:45
Second Decision by Editor
2026-01-09 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-09 03:50
Articles in Press
2026-01-09 03:50
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-03-13 03:12
Publish the Manuscript Online
2026-03-23 08:54
ISSN 1949-8462 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Case Control Study
Article Title Valvular calcification in liver cirrhosis: A comparison with non-cirrhotic cardiovascular controls
Manuscript Source Unsolicited Manuscript
All Author List Maja Vuckovic, Jasenka Grgurić, Frane Paic, Vedran Radonic, Ivana Jurin, Tajana Filipec Kanizaj and Tomislav Letilovic
ORCID
Author(s) ORCID Number
Maja Vuckovic http://orcid.org/0000-0003-4356-2161
Frane Paic http://orcid.org/0000-0001-9688-8582
Tajana Filipec Kanizaj http://orcid.org/0000-0002-7025-0932
Funding Agency and Grant Number
Corresponding Author Frane Paic, Associate Professor, Laboratory for Epigenetic and Molecular Medicine, Department of Medical Biology, School of Medicine, University of Zagreb, Šalata 3, Zagreb 10000, Croatia. fpaic@mef.hr
Key Words Liver cirrhosis; Aortic valve calcification; Mitral annular calcification; Metabolic associated fatty liver disease; Alcohol-related liver disease; Echocardiographic calcium scoring; Logistic regression; Risk stratification; Receiver operating characteristic analysis; Model calibration
Core Tip In a single center observational study of 123 patients with liver cirrhosis (LC) and 123 age- and sex-matched cardiovascular controls, echocardiographic calcium scoring showed that LC - particularly metabolic associated fatty liver disease and alcohol related fatty liver disease - was independently linked to aortic valve calcification, while LC of any etiology strongly predicted mitral annular calcification. Fully adjusted models demonstrated strong discrimination and acceptable calibration, supporting their potential use for risk stratification in LC clinics. These models may help flag high-risk patients who warrant closer echocardiographic surveillance, pending external validation.
Publish Date 2026-03-23 08:54
Citation

Vuckovic M, Grgurić J, Paic F, Radonic V, Jurin I, Filipec Kanizaj T, Letilovic T. Valvular calcification in liver cirrhosis: A comparison with non-cirrhotic cardiovascular controls. World J Cardiol 2026; 18(3): 114077

URL https://www.wjgnet.com/1949-8462/full/v18/i3/114077.htm
DOI https://dx.doi.org/10.4330/wjc.v18.i3.114077
Full Article (PDF) WJC-18-114077-with-cover.pdf
STROBE Statement 114077-STROBE-statement.pdf
Manuscript File 114077_Auto_Edited_102150.docx
Answering Reviewers 114077-answering-reviewers.pdf
Audio Core Tip 114077-audio.mp3
Biostatistics Review Certificate 114077-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 114077-conflict-of-interest-statement.pdf
Copyright License Agreement 114077-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 114077-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 114077-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 114077-non-native-speakers.pdf
Peer-review Report 114077-peer-reviews.pdf
Scientific Misconduct Check 114077-scientific-misconduct-check.png
Scientific Editor Work List 114077-scientific-editor-work-list.pdf
CrossCheck Report 114077-crosscheck-report.pdf