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Articles Published Processes
1/14/2026 8:09:14 AM | Browse: 21 | Download: 66
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Received |
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2025-09-11 01:34 |
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Peer-Review Started |
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2025-09-11 02:54 |
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First Decision by Editorial Office Director |
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2025-09-25 09:05 |
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Return for Revision |
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2025-09-25 09:05 |
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Revised |
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2025-10-15 23:23 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-25 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-25 06:03 |
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Articles in Press |
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2025-11-25 06:03 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-04 02:08 |
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Publish the Manuscript Online |
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2026-01-14 08:09 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Editorial |
| Article Title |
Exploring novel pathways and potential therapeutic targets for diabetic nephropathy: The interplay of podocytes and proximal tubular epithelial cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tarek S Abdelaziz |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tarek S Abdelaziz, FRCP, MD, Department of Nephrology, Kasr Alainy School of Medicine, Cairo University Hospitals, Kasr Alainy, Cairo 11562, Egypt. taroukah5070@kasralainy.edu.eg |
| Key Words |
Diabetic nephropathy; Diabetic kidney disease; Nicotinamide mononucleotide; Podocyte; Proximal tubular epithelial cells |
| Core Tip |
This article sheds light on the interesting study by Zha et al. In this experimental study, a novel pathogenic pathway has been described. A novel concept was also demonstrated, namely the crosstalk between the podocytes and the proximal tubular epithelial cells. The crosstalk involves the secretion of interleukin 6 by the proximal tubular epithelial cells, which aggravates nephrin endocytosis in the podocytes using the Rab5 activation pathway. The application of nicotinamide mononucleotide nicotinamide mononucleotide intercepted the pathway. A new horizon for therapeutics could be further explored using the nicotinamide mononucleotide. |
| Publish Date |
2026-01-14 08:09 |
| Citation |
Abdelaziz TS. Exploring novel pathways and potential therapeutic targets for diabetic nephropathy: The interplay of podocytes and proximal tubular epithelial cells. World J Diabetes 2026; 17(1): 114082 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i1/114082.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i1.114082 |
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