| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Evidence Review |
| Article Title |
Non-invasive strategies for metabolic dysfunction-associated steatotic liver disease assessment and referral in Japan
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yoshihiro Kamada, Yoshio Sumida, Hirokazu Takahashi, Hiroshi Ishiba, Miwa Kawanaka, Toshifumi Tada, Masato Yoneda, Kento Imajo, Yuya Seko, Hideki Fujii and Atsushi Nakajima |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japan Society for the Promotion of Science KAKENHI |
25K11274 |
|
| Corresponding Author |
Hirokazu Takahashi, Professor, Division of Metabolism and Endocrinology, Saga Medical School Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. takahas2@cc.saga-u.ac.jp |
| Key Words |
Fibrosis-4 index; Enhanced liver fibrosis test; Mac-2-binding protein glycosylation isomer; Type 4 collagen 7S; Cytokeratin-18 fragment; Elastography |
| Core Tip |
Metabolic dysfunction-associated steatotic liver disease is highly prevalent, progressing to metabolic dysfunction-associated steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Although liver biopsy is traditional, non-invasive tests (NITs) such as the fibrosis-4 index, enhanced liver fibrosis test, Mac-2-binding protein glycosylation isomer, type IV collagen 7S, cytokeratin-18 fragments, and imaging (elastography/magnetic resonance elastography) now enable accurate and accessible assessment of liver fibrosis. This review summarizes expert consensus on the appropriate use of NITs in Japan, providing evidence-based referral strategies and practical algorithms for primary care and non-hepatologists. Delphi panel results confirm the utility of NITs, but also highlight the need for further longitudinal studies to establish their prognostic value. |
| Publish Date |
2026-01-12 09:50 |
| Citation |
Kamada Y, Sumida Y, Takahashi H, Ishiba H, Kawanaka M, Tada T, Yoneda M, Imajo K, Seko Y, Fujii H, Nakajima A. Non-invasive strategies for metabolic dysfunction-associated steatotic liver disease assessment and referral in Japan. World J Gastroenterol 2026; 32(2): 114097 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i2/114097.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i2.114097 |
