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Articles Published Processes
2/6/2026 6:30:41 AM | Browse: 0 | Download: 0
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Received |
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2025-09-11 08:00 |
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Peer-Review Started |
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2025-09-11 08:00 |
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First Decision by Editorial Office Director |
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2025-10-11 03:25 |
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Return for Revision |
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2025-10-11 03:25 |
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Revised |
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2025-10-23 02:00 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-25 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-25 06:41 |
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Articles in Press |
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2025-12-25 06:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-29 10:18 |
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Publish the Manuscript Online |
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2026-02-06 06:30 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Advances and challenges of chimeric antigen receptor T cell therapy in digestive system malignancies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chen Wang, Jin Zhang, Zi-Ke Chen, Yu-Gang Wang and Min Shi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Pujiang Project of Shanghai Magnolia Talent Plan |
24PJD098 |
| Key Discipline Project of Shanghai Municipal Health System |
2024ZDXK0004 |
| Natural Science Foundation of the Science and Technology Commission of Shanghai Municipality |
23ZR1458300 |
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| Corresponding Author |
Min Shi, Chief Physician, MD, Professor, Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Changning District, Shanghai 200336, China. sm1790@shtrhospital.com |
| Key Words |
Chimeric antigen receptor T cell therapy; Digestive system tumors; Gastrointestinal cancers; Chimeric antigen receptor design; Immunotherapy |
| Core Tip |
Chimeric antigen receptor T cell therapy (CAR) has achieved remarkable success in hematologic cancers but faces unique barriers in solid tumors of the digestive system. This article highlights recent progress in optimizing antigen selection, CAR engineering, and delivery strategies, while discussing tumor-specific targets and clinical trials in gastric, colorectal, esophageal, hepatic, and pancreatic cancers. By addressing challenges such as the tumor microenvironment and therapeutic resistance, we provide perspectives on advancing CAR T cell therapy immunotherapy toward safe, effective, and durable treatments for gastrointestinal malignancies. |
| Publish Date |
2026-02-06 06:30 |
| Citation |
Wang C, Zhang J, Chen ZK, Wang YG, Shi M. Advances and challenges of chimeric antigen receptor T cell therapy in digestive system malignancies. World J Clin Oncol 2026; 17(2): 114107 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i2/114107.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i2.114107 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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