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Articles Published Processes
1/15/2026 8:12:50 AM | Browse: 1 | Download: 1
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Received |
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2025-09-15 08:50 |
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Peer-Review Started |
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2025-09-15 08:50 |
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First Decision by Editorial Office Director |
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2025-09-28 06:46 |
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Return for Revision |
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2025-09-28 06:46 |
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Revised |
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2025-10-11 06:54 |
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Publication Fee Transferred |
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2025-10-13 01:47 |
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Second Decision by Editor |
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2025-12-01 03:10 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-01 09:41 |
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Articles in Press |
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2025-12-01 09:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-07 03:09 |
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Publish the Manuscript Online |
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2026-01-15 08:12 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Nicotinamide adenine dinucleotide inhibits the production of reactive oxygen species and myocardial cell pyroptosis caused by hypoxia/re-oxygenation injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shuang Dong, Yun-Qi Liu, Yi-Jun Tu, Shan Gao, Yu-Jie Liu, Chang Liu and Zuo-Wei Pei |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82303572 |
| Department of Science and Technology of Liaoning Province (China) |
2024-MS-285 |
| the “Peak Climbing Plan” of Dalian Central Hospital |
2023ZZ051 |
| the Dalian Central Hospital-initiated project of “Provincial Key Specialty” |
2023SZ015 |
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| Corresponding Author |
Chang Liu, PhD, Central Laboratory, Central Hospital of Dalian University of Technology, No. 826 Southwest Road, Dalian 116033, Liaoning Province, China. liuch2024@dlut.edu.cn |
| Key Words |
Nicotinamide adenine dinucleotide; Ischemia/reperfusion injury; Pyroptosis; Oxidative stress; Hypoxia/re-oxygenation |
| Core Tip |
Myocardial ischemia/reperfusion (I/R) was a hazardous factor affecting the therapeutic effects of coronary heart disease, especially acute myocardial infarction. The oxidized form of nicotinamide adenine dinucleotide (NAD)-NAD+ is crucial for various cellular functions. This study explored the effects and mechanisms of NAD+ on cell death caused by I/R injury in H9c2 cells. The results showed that supplementing with NAD+ can protect H9c2 cells from pyroptosis induced by I/R injury. Mechanistically, NAD+ supplementation reduces pyroptosis in H9c2 cells triggered by hypoxia/re-oxygenation by inhibiting the activation of the NOD-like receptor pyrin domain-containing 3 inflammasome. These results indicate that NAD+ supplementation could be a promising therapeutic strategy for I/R injury. |
| Publish Date |
2026-01-15 08:12 |
| Citation |
Dong S, Liu YQ, Tu YJ, Gao S, Liu YJ, Liu C, Pei ZW. Nicotinamide adenine dinucleotide inhibits the production of reactive oxygen species and myocardial cell pyroptosis caused by hypoxia/re-oxygenation injury. World J Cardiol 2026; 18(1): 114108 |
| URL |
https://www.wjgnet.com/1949-8462/full/v18/i1/114108.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v18.i1.114108 |
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