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Articles Published Processes
1/20/2026 2:54:06 AM | Browse: 4 | Download: 15
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Received |
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2025-09-15 02:29 |
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Peer-Review Started |
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2025-09-15 02:29 |
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First Decision by Editorial Office Director |
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2025-10-13 07:35 |
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Return for Revision |
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2025-10-13 07:35 |
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Revised |
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2025-11-04 14:42 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-09 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-10 08:20 |
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Articles in Press |
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2025-12-10 08:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-12 02:51 |
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Publish the Manuscript Online |
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2026-01-20 02:54 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Strengthening causal inference and analytical rigor in the Wumei Pills-Lactobacillus reuteri-intestinal stem cell axis for chemotherapy-induced mucositis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rui-Li Yang, Qing Lu, Er-Min Liang and Hong-Cheng Luo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hong-Cheng Luo, MD, Division of Vascular Surgery, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, No. 3025 Shennan Zhong Road, Futian District, Hong Kong 999077, China. drlhc96@163.com |
| Key Words |
Chemotherapy-induced mucositis; Wumei Pills; Lactobacillus reuteri; Intestinal stem cells; Wnt/β-catenin |
| Core Tip |
In this methodological critique, we highlight six key areas to bolster the evidence that Wumei Pills (WMP) and Lactobacillus reuteri mitigate chemotherapy-induced mucositis via intestinal stem cell activation. We urge the authors to incorporate tissue-level inflammation indices (myeloperoxidase, interleukin-1β, immune cell infiltration) rather than relying solely on serum cytokines and lipopolysaccharide. We also suggest causality-verification experiments (probiotic depletion or fecal microbiota transplantation) to confirm the WMP-microbiota-intestinal stem cell linkage. The letter recommends more rigorous validation of Wnt/β-catenin signaling (e.g., demonstrating β-catenin nuclear translocation and downstream target gene activation), stronger study design practices (sample size calculation, blinded outcome assessment, accounting for cage effects, and false-discovery rate adjustments), dose-response and safety evaluations for WMP/Lactobacillus reuteri, and expanded experimental conditions to test the robustness of the therapeutic effect across different biological contexts. These improvements will help substantiate the mechanistic claims and translational potential of this promising gut microbiota-mediated therapy. |
| Publish Date |
2026-01-20 02:54 |
| Citation |
Yang RL, Lu Q, Liang EM, Luo HC. Strengthening causal inference and analytical rigor in the Wumei Pills-Lactobacillus reuteri-intestinal stem cell axis for chemotherapy-induced mucositis. World J Stem Cells 2026; 18(1): 114114 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i1/114114.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i1.114114 |
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