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Articles Published Processes
1/20/2026 2:54:05 AM | Browse: 59 | Download: 161
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Received |
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2025-09-12 10:09 |
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Peer-Review Started |
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2025-09-12 10:09 |
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First Decision by Editorial Office Director |
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2025-10-13 07:34 |
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Return for Revision |
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2025-10-13 07:34 |
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Revised |
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2025-10-15 12:07 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-17 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-24 09:27 |
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Articles in Press |
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2025-11-24 09:27 |
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Edit the Manuscript by Language Editor |
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2025-11-29 21:46 |
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Typeset the Manuscript |
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2026-01-12 02:43 |
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Publish the Manuscript Online |
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2026-01-20 02:54 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Aging puzzle: A closer look on the complex dilemma of autologous stem cell therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mahmood S Choudhery, Taqdees Arif and Ruhma Mahmood |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mahmood S Choudhery, Associate Professor, Department of Human Genetics and Molecular Biology, University of Health Sciences Lahore, Khayaban-e-Jamia Punjab, Block D Muslim Town, Lahore 56000, Punjab, Pakistan. ms20031@yahoo.com |
| Key Words |
Regenerative medicine; Autologous stem cell therapy; Regenerative potential; Aging; Donor age; Optimizing therapy; Aged patients |
| Core Tip |
Stem cell-based therapies, particularly autologous stem cell therapy, hold strong promise for treating age-related degenerative diseases by reducing risks of immune rejection and graft-vs-host disease. However, the therapeutic efficacy of patient-derived stem cells is often compromised by aging and disease-related decline in their regenerative capacity. To address these limitations, several strategies have been developed, including hypoxic preconditioning, genetic modification, growth factor supplementation, three-dimensional culturing, hybrid approaches, use of bioactive compounds, mesenchymal stem cell-derived exosomes, targeted activation of signaling pathways and cryopreservation of youthful stem cells. These approaches aim to restore or preserve stem cell functionality, enhancing therapeutic outcomes in elderly patients. |
| Publish Date |
2026-01-20 02:54 |
| Citation |
Choudhery MS, Arif T, Mahmood R. Aging puzzle: A closer look on the complex dilemma of autologous stem cell therapy. World J Stem Cells 2026; 18(1): 114119 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i1/114119.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i1.114119 |
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