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Articles Published Processes
2/28/2026 8:32:46 AM | Browse: 34 | Download: 108
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Received |
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2025-09-16 06:14 |
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Peer-Review Started |
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2025-09-16 06:14 |
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First Decision by Editorial Office Director |
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2025-10-17 06:56 |
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Return for Revision |
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2025-10-17 06:56 |
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Revised |
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2025-10-29 08:15 |
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Publication Fee Transferred |
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2025-11-13 01:48 |
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Second Decision by Editor |
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2025-12-09 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-09 09:04 |
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Articles in Press |
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2025-12-09 09:04 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-10 08:58 |
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Publish the Manuscript Online |
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2026-02-28 08:32 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Minireviews |
| Article Title |
Emotion-cognition dysregulation in major depression: Multidimensional biases, neural circuit imbalance, and translational opportunities
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi Gu, Yi-Xu Wang, Wen-Juan Xia and Jun Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jun Wang, Associate Professor, PhD, Department of Psychiatry, Wuxi Mental Health Center (Affiliated Mental Health Center of Jiangnan University), No. 156 Binhu District, Wuxi 214151, Jiangsu Province, China. woodfish2@jiangnan.edu.cn |
| Key Words |
Major depressive disorder; Emotion-cognition dysregulation; Amygdala-prefrontal circuitry; Attentional bias; Amotion regulation; Biomarkers |
| Core Tip |
This review reframes major depression as an emotion–cognition dysregulation syndrome characterized by a limbic-prefrontal imbalance and large-scale network disruption. By integrating behavioral signatures (negative attention/memory bias, impaired reappraisal) with neural markers (amygdala/insula hyperreactivity, weakened prefrontal control, default mode network-frontoparietal control network/salience network dyscoupling), it outlines composite biomarkers for diagnosis, stratified risk prediction, and mechanism-guided therapies (e.g., imaging-informed neuromodulation). The field now needs standardized tasks and longitudinal multimodal designs to operationalize precision psychiatry. |
| Publish Date |
2026-02-28 08:32 |
| Citation |
Gu Y, Wang YX, Xia WJ, Wang J. Emotion-cognition dysregulation in major depression: Multidimensional biases, neural circuit imbalance, and translational opportunities. World J Psychiatry 2026; 16(3): 114153 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i3/114153.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i3.114153 |
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