| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Armando Curto, Michele Tanturli, Rocco Gabriele Iamello, Pietro Rossi, Giulia Mengozzi, Leonardo Dei, Tommaso Mello, Tommaso Innocenti, Gabriele Dragoni, Andrea Galli and Erica Nicola Lynch |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Erica Nicola Lynch, Consultant, MD, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, Gastroenterology Research Unit, University of Florence, Largo Brambilla 3, Florence 50134, Tuscany, Italy. ericanicola.lynch@unifi.it |
| Key Words |
Chronotype; Daytime sleepiness; Cholestatic disorders; Mental; Muscular; Primary biliary cholangitis; Primary sclerosing cholangitis |
| Core Tip |
In non-cirrhotic primary biliary cholangitis, fatigue burden is similar to healthy controls and primary sclerosing cholangitis, but its phenotype is predominantly muscular (approximately 69%), independent of sex, age-adjusted employment, or routine disease metrics; daytime sleepiness and sleep duration are low/normal, and chronotype clusters in the intermediate range, with age - not disease - driving greater morningness. Primary sclerosing cholangitis shows a similar (weaker) direction of effect. These findings support routine fatigue phenotyping and muscle-focused interventions over cholestasis-directed therapies, and argue for objective endpoints (e.g., 31phosphorus magnetic resonance spectroscopy, actigraphy) in future trials. |
| Publish Date |
2026-02-12 11:20 |
| Citation |
Curto A, Tanturli M, Iamello RG, Rossi P, Mengozzi G, Dei L, Mello T, Innocenti T, Dragoni G, Galli A, Lynch EN. Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls. World J Hepatol 2026; 18(2): 114206 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i2/114206.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i2.114206 |
