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Articles Published Processes
2/12/2026 11:20:20 AM | Browse: 135 | Download: 614
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Received |
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2025-09-15 07:45 |
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Peer-Review Started |
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2025-09-15 07:45 |
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First Decision by Editorial Office Director |
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2025-09-25 08:30 |
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Return for Revision |
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2025-09-25 08:30 |
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Revised |
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2025-10-05 19:47 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-12 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-12 08:13 |
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Articles in Press |
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2025-12-12 08:13 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-04 00:41 |
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Publish the Manuscript Online |
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2026-02-12 11:20 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Armando Curto, Michele Tanturli, Rocco Gabriele Iamello, Pietro Rossi, Giulia Mengozzi, Leonardo Dei, Tommaso Mello, Tommaso Innocenti, Gabriele Dragoni, Andrea Galli and Erica Nicola Lynch |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Erica Nicola Lynch, Consultant, MD, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, Gastroenterology Research Unit, University of Florence, Largo Brambilla 3, Florence 50134, Tuscany, Italy. ericanicola.lynch@unifi.it |
| Key Words |
Chronotype; Daytime sleepiness; Cholestatic disorders; Mental; Muscular; Primary biliary cholangitis; Primary sclerosing cholangitis |
| Core Tip |
In non-cirrhotic primary biliary cholangitis, fatigue burden is similar to healthy controls and primary sclerosing cholangitis, but its phenotype is predominantly muscular (approximately 69%), independent of sex, age-adjusted employment, or routine disease metrics; daytime sleepiness and sleep duration are low/normal, and chronotype clusters in the intermediate range, with age - not disease - driving greater morningness. Primary sclerosing cholangitis shows a similar (weaker) direction of effect. These findings support routine fatigue phenotyping and muscle-focused interventions over cholestasis-directed therapies, and argue for objective endpoints (e.g., 31phosphorus magnetic resonance spectroscopy, actigraphy) in future trials. |
| Publish Date |
2026-02-12 11:20 |
| Citation |
Curto A, Tanturli M, Iamello RG, Rossi P, Mengozzi G, Dei L, Mello T, Innocenti T, Dragoni G, Galli A, Lynch EN. Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls. World J Hepatol 2026; 18(2): 114206
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i2/114206.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i2.114206 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
