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Articles Published Processes
1/16/2026 11:29:29 AM | Browse: 0 | Download: 0
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Received |
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2025-09-15 02:23 |
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Peer-Review Started |
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2025-09-15 02:23 |
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First Decision by Editorial Office Director |
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2025-10-30 09:23 |
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Return for Revision |
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2025-10-30 09:23 |
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Revised |
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2025-11-14 03:07 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-04 02:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-04 03:16 |
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Articles in Press |
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2025-12-04 03:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-30 09:34 |
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Publish the Manuscript Online |
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2026-01-16 11:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Beyond anti-inflammatory strategies: Epigenetic targets as emerging therapeutic frontiers in acute pancreatitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Li-Ping Liang, Le Zhang, Dan-Dan Jin, Shao-Heng Zhang and Le Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shenzhen Medical Research Fund |
No. A2403044 |
| National Nature Science Foundation of China |
No. 82200612 |
| Guangdong Basic and Applied Basic Research Foundation |
No. 2023A1515111183 |
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| Corresponding Author |
Le Liu, MD, PhD, Principal Investigator, Shenzhen Clinical Research Center for Digestive Disease, Shenzhen Hospital, Southern Medical University, No. 1333 Xinhu Road, Shenzhen 518000, Guangdong Province, China. 1402744723@smu.edu.cn |
| Key Words |
Acute pancreatitis; Epigenetic regulation; Rutaecarpine; FBXW11; EZH2 |
| Core Tip |
Acute pancreatitis (AP) remains without effective mechanism-based therapy beyond supportive care. This editorial emphasizes epigenetic regulation as an emerging therapeutic frontier, highlighting how the traditional Chinese medicine alkaloid rutaecarpine protects against AP via enhancer of EZH2-mediated repression of FBXW11. By integrating evidence on FBXW11 as an inflammatory biomarker, the pleiotropic actions of rutaecarpine, and the clinical availability of EZH2 inhibitors, this article outlines an epigenetic, multi-target framework for future AP interventions. |
| Publish Date |
2026-01-16 11:29 |
| Citation |
Liang LP, Zhang L, Jin DD, Zhang SH, Liu L. Beyond anti-inflammatory strategies: Epigenetic targets as emerging therapeutic frontiers in acute pancreatitis. World J Gastroenterol 2026; 32(3): 114229 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i3/114229.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i3.114229 |
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