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Articles Published Processes
11/10/2014 7:09:00 PM | Browse: 1017 | Download: 1517
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Received |
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2014-05-20 20:00 |
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Peer-Review Started |
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2014-05-21 16:47 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-06-05 09:27 |
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Revised |
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2014-06-21 16:56 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-07-16 13:00 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-07-16 13:13 |
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Articles in Press |
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2014-07-16 17:58 |
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Edit the Manuscript by Language Editor |
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2014-07-23 20:59 |
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Typeset the Manuscript |
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2014-10-24 15:31 |
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Publish the Manuscript Online |
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2014-11-10 19:10 |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Autobiography |
| Article Title |
Therapeutic effect of a hydroxynaphthoquinone fraction on dextran sulfate sodium-induced ulcerative colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Liang Zhang, Hua-Ying Fan, Ming-Yan Yang, Zuo-Kai Zhang and Ke Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Development and Plan of Yantai |
2013ZH086 |
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| Corresponding Author |
Ke Liu, MD, College of Life Science, Jilin University, No. 2699 Qianjin Street, Changchun 130012, Jilin Province, China. liuke201116@163.com |
| Key Words |
Arnebia euchroma (Royle) Johnst; Hydroxynaphthoquinones; Inflammatory bowel disease; Dextran sulfate sodium-induced ulcerative colitis; Nuclear factor-B activation |
| Core Tip |
To date, there is still an urgent need for more effective and safe therapeutic approaches for treatment of inflammatory bowel disease. We obtain a hydroxynaphthoquinone mixture (HM) from Zicao, a traditional Chinese medicine. Previously, HM demonstrates favourable therapeutic effect on TNBS-induced colitis. To exclude the therapeutic effect is limited to TNBS-induced colitis. We evaluated the effect of HM in dextran sulfate sodium (DSS)-induced ulcerative colitis. Similarly, we found that HM was beneficial to DSS-induced colitis. The underlying mechanism may associate with its regulation of TNF-α level and NF-κB activity. All these provide support for its further development and clinical application. |
| Publish Date |
2014-11-10 19:10 |
| Citation |
Zhang ZL, Fan HY, Yang MY, Zhang ZK, Liu K. Therapeutic effect of a hydroxynaphthoquinone fraction on dextran sulfate sodium-induced ulcerative colitis. World J Gastroenterol 2014; 20(41): 15310-15318 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i41/15310.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i41.15310 |
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