Publication Name	World Journal of Gastroenterology
Manuscript ID	11424
Country	China

Received	2014-05-20 20:00
Peer-Review Started	2014-05-21 16:47
To Make the First Decision	2014-05-29 19:04
Return for Revision	2014-06-05 09:27
Revised	2014-06-21 16:56
Second Decision	2014-07-16 13:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-16 13:13
Articles in Press	2014-07-16 17:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-23 20:59
Typeset the Manuscript	2014-10-24 15:31
Publish the Manuscript Online	2014-11-10 19:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Autobiography
Article Title	Therapeutic effect of a hydroxynaphthoquinone fraction on dextran sulfate sodium-induced ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Liang Zhang, Hua-Ying Fan, Ming-Yan Yang, Zuo-Kai Zhang and Ke Liu
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Development and Plan of Yantai 2013ZH086
Corresponding Author	Ke Liu, MD, College of Life Science, Jilin University, No. 2699 Qianjin Street, Changchun 130012, Jilin Province, China. liuke201116@163.com
Key Words	Arnebia euchroma (Royle) Johnst; Hydroxynaphthoquinones; Inflammatory bowel disease; Dextran sulfate sodium-induced ulcerative colitis; Nuclear factor-B activation
Core Tip	To date, there is still an urgent need for more effective and safe therapeutic approaches for treatment of inflammatory bowel disease. We obtain a hydroxynaphthoquinone mixture (HM) from Zicao, a traditional Chinese medicine. Previously, HM demonstrates favourable therapeutic effect on TNBS-induced colitis. To exclude the therapeutic effect is limited to TNBS-induced colitis. We evaluated the effect of HM in dextran sulfate sodium (DSS)-induced ulcerative colitis. Similarly, we found that HM was beneficial to DSS-induced colitis. The underlying mechanism may associate with its regulation of TNF-α level and NF-κB activity. All these provide support for its further development and clinical application.
Publish Date	2014-11-10 19:10
Citation	Zhang ZL, Fan HY, Yang MY, Zhang ZK, Liu K. Therapeutic effect of a hydroxynaphthoquinone fraction on dextran sulfate sodium-induced ulcerative colitis. World J Gastroenterol 2014; 20(41): 15310-15318
URL	http://www.wjgnet.com/1007-9327/full/v20/i41/15310.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i41.15310

Full Article (PDF)	WJG-20-15310.pdf
Full Article (Word)	WJG-20-15310.doc
Manuscript File	11424-Review.doc
Answering Reviewers	11424-Answering reviewers.pdf
Copyright License Agreement	11424-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11424-Language certificate.pdf
Peer-review Report	11424-Peer reviews.pdf
Scientific Misconduct Check	11424-CrossCheck.jpg
Scientific Editor Work List	11424-Scientific editor work list.pdf