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1/14/2026 8:09:11 AM | Browse: 152 | Download: 514
Publication Name World Journal of Diabetes
Manuscript ID 114251
Country China
Received
2025-09-15 00:28
Peer-Review Started
2025-09-15 08:13
First Decision by Editorial Office Director
2025-10-13 07:27
Return for Revision
2025-10-13 07:27
Revised
2025-10-24 22:15
Publication Fee Transferred
Second Decision by Editor
2025-11-19 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-11-19 06:09
Articles in Press
2025-11-19 06:09
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-04 05:55
Publish the Manuscript Online
2026-01-14 08:09
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Nutrition & Dietetics
Manuscript Type Letter to the Editor
Article Title Exosomal miR-375-3p as a mediator of pancreas-liver crosstalk in impaired hepatic glycogenesis
Manuscript Source Unsolicited Manuscript
All Author List Tian-Han Xu and Dong-Mei Wang
ORCID
Author(s) ORCID Number
Dong-Mei Wang http://orcid.org/0000-0002-9922-5626
Funding Agency and Grant Number
Corresponding Author Dong-Mei Wang, Academic Fellow, PhD, Professor, Department of Gastrointestinal Surgery, Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, 68 Gehu Middle Road, Changzhou 213000, Jiangsu Province, China. fautywang@163.com
Key Words Type 2 diabetes mellitus; Hepatic glycogenesis; Pancreas-liver crosstalk; Exosome; miR-375-3p; Pancreatic β cells; Hepatocytes
Core Tip Xu et al revealed that pancreatic β-cell-derived exosomal miR-375-3p inhibits Rbpj expression in hepatocytes, leading to the suppression of the AKT/GSK signaling pathway and impaired hepatic glycogenesis. Their study identified a novel exosome-mediated pancreas-liver communication axis in the progression of diabetes, underscoring the promising role of exosomal microRNAs as both diagnostic biomarkers and therapeutic targets.
Publish Date 2026-01-14 08:09
Citation

Xu TH, Wang DM. Exosomal miR-375-3p as a mediator of pancreas-liver crosstalk in impaired hepatic glycogenesis. World J Diabetes 2026; 17(1): 114251

URL https://www.wjgnet.com/1948-9358/full/v17/i1/114251.htm
DOI https://dx.doi.org/10.4239/wjd.v17.i1.114251
Full Article (PDF) WJD-17-114251-with-cover.pdf