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Articles Published Processes
4/23/2026 11:05:46 AM | Browse: 5 | Download: 25
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Received |
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2025-09-15 00:39 |
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Peer-Review Started |
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2025-09-15 00:39 |
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First Decision by Editorial Office Director |
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2025-10-11 05:39 |
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Return for Revision |
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2025-10-11 05:39 |
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Revised |
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2025-10-13 14:24 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-06 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-07 01:53 |
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Articles in Press |
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2026-01-07 01:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-31 07:14 |
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Publish the Manuscript Online |
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2026-04-23 11:05 |
| ISSN |
2222-0682 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
Interleukin-1 receptor antagonist autoantibodies in Still’s disease: Mechanistic insights and laboratory testing
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Abdellatif Bouayad |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Abdellatif Bouayad, Associate Professor, MD, Department of Immunology, Mohammed First University, Faculty of Medicine and Pharmacy Oujda, 4867 Oujda l’Université, Oujda-Angad 4867, Oriental, Morocco. a.bouayad@ump.ac.ma |
| Key Words |
Still’s disease; Interleukin-1 receptor antagonist autoantibodies; Pathogenesis; Enzyme-linked immunosorbent; Isoelectric focusing; Western blot; Interleukin-1β signaling reporter cell assays |
| Core Tip |
Still’s disease is a rare, severe systemic inflammatory disorder characterized by elevated levels of neutralizing interleukin-1 receptor antagonist autoantibodies. Their induction is thought to result from a combination of host-related factors, such as human leukocyte antigen class II alleles, and interleukin-1 receptor antagonist intrinsic factors, including hyperphosphorylation. Despite frequent detection of these antibodies using immunoassays and functional cell-based assays, the lack of assay standardization limits their clinical utility. At present, their presence is best regarded as a marker of underlying immune dysregulation rather than a direct pathogenic driver. |
| Publish Date |
2026-04-23 11:05 |
| Citation |
Bouayad A. Interleukin-1 receptor antagonist autoantibodies in Still’s disease: Mechanistic insights and laboratory testing. World J Methodol 2026; 16(2): 114269 |
| URL |
https://www.wjgnet.com/2222-0682/full/v16/i2/114269.htm |
| DOI |
https://dx.doi.org/10.5662/wjm.v16.i2.114269 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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