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2/26/2026 10:19:37 AM | Browse: 3 | Download: 1
Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 114286
Country China
Received
2025-10-28 09:00
Peer-Review Started
2025-10-28 09:00
First Decision by Editorial Office Director
2025-11-18 02:25
Return for Revision
2025-11-18 02:25
Revised
2025-12-03 14:26
Publication Fee Transferred
2025-12-09 07:33
Second Decision by Editor
2026-01-06 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-06 04:49
Articles in Press
2026-01-06 04:49
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-02-05 07:10
Publish the Manuscript Online
2026-02-26 10:19
ISSN 1948-9366 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Individual chemotherapy for patients colorectal cancer based on patient-derived tumor-like cell clusters
Manuscript Source Unsolicited Manuscript
All Author List Fu-Lin Lin, Li-Min Zhou, Yun-Jie Ye, Xiao-Long Luo, Xue-Lin Ji, Si-Qi Chen, Ji-Guang Xie, Bing-Feng Jin and Zhen-Dong Liu
ORCID
Author(s) ORCID Number
Zhen-Dong Liu http://orcid.org/0000-0002-8339-4054
Funding Agency and Grant Number
Funding Agency Grant Number
Traditional Chinese Medicine Science and Technology Development Plan in Zhejiang Province of China 2022ZB131
Corresponding Author Zhen-Dong Liu, MD, Department of Medical Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. liudong761@163.com
Key Words Colorectal cancer; Chemotherapy; Drug assay; Precision medicine
Core Tip Colorectal cancer (CRC) is one of the most common malignant tumors. Currently, FOLFOX serves as the standard postoperative adjuvant chemotherapy for resectable CRC, while FOLFIRI and FOLFOXIRI are widely used for metastatic or recurrent disease, typically in combination with targeted therapies. The microtumor patient-derived tumor-like cell clusters (PTC) drug sensitivity testing technology involves establishing an in vitro tumor model highly similar to the patient's actual tumor using their own tumor cells. This model is then utilized for drug sensitivity testing, enabling the screening and recommendation of effective treatment regimens while filtering out ineffective options based on therapeutic efficacy. This study primarily evaluates the feasibility of using PTC to guide individualized chemotherapy for CRC patients.
Publish Date 2026-02-26 10:19
Citation

Lin FL, Zhou LM, Ye YJ, Luo XL, Ji XL, Chen SQ, Xie JG, Jin BF, Liu ZD. Individual chemotherapy for patients colorectal cancer based on patient-derived tumor-like cell clusters. World J Gastrointest Surg 2026; 18(2): 114286

URL https://www.wjgnet.com/1948-9366/full/v18/i2/114286.htm
DOI https://dx.doi.org/10.4240/wjgs.v18.i2.114286
Full Article (PDF) WJGS-18-114286-with-cover.pdf
Manuscript File 114286_Auto_Edited_084219.docx
Answering Reviewers 114286-answering-reviewers.pdf
Audio Core Tip 114286-audio.mp3
Biostatistics Review Certificate 114286-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 114286-conflict-of-interest-statement.pdf
Copyright License Agreement 114286-copyright-assignment.pdf
Institutional Review Board Approval Form or Document 114286-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 114286-non-native-speakers.pdf
Supplementary Material 114286-supplementary-material.pdf
Peer-review Report 114286-peer-reviews.pdf
Scientific Misconduct Check 114286-scientific-misconduct-check.png
Scientific Editor Work List 114286-scientific-editor-work-list.pdf
CrossCheck Report 114286-crosscheck-report.pdf