| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Case Report |
| Article Title |
De novo schizophrenia after liver transplantation: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ji-Wei Qin, Jian-Cheng Wu, Hao Zheng, Can Qi, Ze-Bin Zhu, Xue-Feng Li, Ning Wang, Xiao-Dong Yuan, Zhi-Jun Xu, Wei Wu, Shu-Geng Zhang and Björn Nashan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Anhui Provincial Outstanding Youth Research Foundation for Higher Education Institutions of China |
2022AH020077 |
|
| Corresponding Author |
Björn Nashan, FACS, FRCS (Gen Surg), MD, PhD, Professor, Department of Liver Transplantation, The First Affiliated Hospital of USTC, Hezeji Street, Shushan District, Hefei City, Hefei 230000, Anhui Province, China. bjoern.nashan@gmail.com |
| Key Words |
De novo schizophrenia; Post-transplant psychosis; Calcineurin inhibitor neurotoxicity; Tacrolimus; Late-onset schizophrenia; Liver transplantation; Case report |
| Core Tip |
We present the inaugural instance of new-onset schizophrenia occurring within one year post-liver transplantation in a 63-year-old female patient. The diagnosis was determined using structured interviews, sequential Positive and Negative Syndrome Scale scores, and thorough exclusion of metabolic, viral, and toxic variables. Following the commencement of antipsychotic treatment alongside low-dose tacrolimus and mycofenolate mofetil immunosuppression, the patient showed rapid improvement of symptoms, indicating calcineurin-inhibitor neurotoxicity as a direct catalyst; and surgical stress and anesthesia likely exacerbated individual vulnerability. This instance highlights the necessity for proactive neuropsychiatric monitoring and tailored immunosuppression in liver transplant recipients. |
| Publish Date |
2026-01-27 10:12 |
| Citation |
Qin JW, Wu JC, Zheng H, Qi C, Zhu ZB, Li XF, Wang N, Yuan XD, Xu ZJ, Wu W, Zhang SG, Nashan B. De novo schizophrenia after liver transplantation: A case report. World J Hepatol 2026; 18(1): 114291 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i1/114291.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i1.114291 |
