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Articles Published Processes
5/27/2026 8:10:54 AM | Browse: 0 | Download: 0
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Received |
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2025-09-16 06:41 |
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Peer-Review Started |
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2025-09-16 06:41 |
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First Decision by Editorial Office Director |
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2025-11-19 10:19 |
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Return for Revision |
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2025-11-19 10:19 |
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Revised |
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2025-12-01 18:37 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-02 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-03 00:16 |
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Articles in Press |
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2026-02-03 00:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-31 07:01 |
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Publish the Manuscript Online |
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2026-05-27 08:10 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Beyond gluten-free diet: Novel therapeutic frontiers in celiac disease armamentarium
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sandeep K Mundhra and Rakesh K Kochhar |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Rakesh K Kochhar, DM, Professor, Department of Gastroenterology, Paras Hospital, Paras Hospital Road, Sector-22, Panchkula 134109, Haryana, India. dr_kochhar@hotmail.com |
| Key Words |
Celiac disease; Gluten-free diet; Celiac disease pathophysiology; Celiac disease treatment; Novel therapies in celiac disease |
| Core Tip |
Celiac disease is managed with a gluten-free diet, which is difficult to sustain and often fails to achieve full mucosal recovery. Advances in disease pathogenesis have led to novel therapies, including gluten-detoxifying enzymes, gluten-sequestering polymers, barrier stabilizers, tissue transglutaminase-2 inhibitors, human leukocyte antigen-DQ antagonists, cytokine-directed biologics, and tolerance-inducing strategies such as nanoparticle-based therapies. This review summarizes the current therapeutic pipeline, discusses the challenges of translating emerging therapies into routine practice, and highlights how future management is likely to evolve towards personalized, multimodal approaches that integrate dietary management with safe and effective adjunctive therapies. |
| Publish Date |
2026-05-27 08:10 |
| Citation |
Mundhra SK, Kochhar RK. Beyond gluten-free diet: Novel therapeutic frontiers in celiac disease armamentarium. World J Gastrointest Pharmacol Ther 2026; 17(2): 114292 |
| URL |
https://www.wjgnet.com/2150-5349/full/v17/i2/114292.htm |
| DOI |
https://dx.doi.org/10.4292/wjgpt.v17.i2.114292 |
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