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Articles Published Processes
2/14/2026 6:34:07 AM | Browse: 60 | Download: 152
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Received |
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2025-09-16 06:47 |
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Peer-Review Started |
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2025-09-16 06:47 |
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First Decision by Editorial Office Director |
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2025-10-21 06:45 |
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Return for Revision |
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2025-10-21 06:45 |
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Revised |
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2025-11-02 10:20 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-20 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-20 09:07 |
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Articles in Press |
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2026-01-20 09:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-04 02:22 |
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Publish the Manuscript Online |
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2026-02-14 06:34 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Editorial |
| Article Title |
Targeting mitochondrial quality control in osteoarthritis with GrpE-like 1-loaded synovial mesenchymal stromal/stem cell small extracellular vesicles
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhuo-Jin Shi, Xiao-Mei Ying and Wei Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wei Liu, Department of Oral Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. liuwei1982@zju.edu.cn |
| Key Words |
Osteoarthritis; Extracellular vesicles; Synovial mesenchymal stem cells; GrpE-like 1; PTEN-induced kinase 1/Parkin-mediated mitophagy |
| Core Tip |
This editorial frames GrpE-like 1-loaded synovial extracellular vesicles as a mitochondria-centric strategy for osteoarthritis and translates bench evidence into an executable roadmap. We operationalize identity/purity panels, dual-metric dose (particles and protein), shared exposure anchors, and a mechanism-linked potency assay for lot release and comparability. Early trials should prespecify Outcome Measures in Rheumatology-Osteoarthritis Research Society International endpoints with quantitative magnetic resonance imaging cartilage thickness as an exploratory structural anchor. Transparent method registration and time-bounded regulatory messaging are emphasized to improve reproducibility, cross-study comparison, and readiness for first-in-human evaluation. |
| Publish Date |
2026-02-14 06:34 |
| Citation |
Shi ZJ, Ying XM, Liu W. Targeting mitochondrial quality control in osteoarthritis with GrpE-like 1-loaded synovial mesenchymal stromal/stem cell small extracellular vesicles. World J Stem Cells 2026; 18(2): 114303 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i2/114303.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i2.114303 |
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