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Articles Published Processes
11/26/2025 3:57:03 AM | Browse: 14 | Download: 83
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Received |
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2025-09-16 06:25 |
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Peer-Review Started |
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2025-09-16 06:25 |
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First Decision by Editorial Office Director |
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2025-09-29 07:28 |
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Return for Revision |
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2025-09-29 07:28 |
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Revised |
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2025-10-01 11:00 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-05 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-05 08:26 |
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Articles in Press |
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2025-11-05 08:26 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-19 01:21 |
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Publish the Manuscript Online |
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2025-11-26 03:57 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Exosomal delivery of GrpE-like 1 from synovial mesenchymal stem cells activates PINK1-mediated mitophagy for cartilage repair in osteoarthritis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Soumya Deep Phadikar, Ramya Lakshmi Rajendran, Sathish Muthu, Prakash Gangadaran and Byeong-Cheol Ahn |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Science Research Program |
NRF-2022R1I1A1A01068652 |
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| Corresponding Author |
Byeong-Cheol Ahn, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, South Korea. abc2000@knu.ac.kr |
| Key Words |
Osteoarthritis; Exosomes; Synovial mesenchymal stem cell; GrpE-like 1; PINK1; Mitophagy; Mitochondrial quality control; Cartilage repair |
| Core Tip |
This study identifies GrpE-like 1 (GRPEL1) as a mitophagy-related biomarker that is suppressed in osteoarthritis and demonstrates that exosomes derived from synovial mesenchymal stem cells can be engineered to deliver GRPEL1 to chondrocytes. Delivery of GRPEL1 via these exosomes restores mitochondrial homeostasis through PINK1-dependent mitophagy, reduces oxidative damage, preserves the extracellular matrix, and improves histological outcomes in a rat model of osteoarthritis. This represents a translationally promising, cell-free strategy for disease modification in osteoarthritis. |
| Publish Date |
2025-11-26 03:57 |
| Citation |
Phadikar SD, Rajendran RL, Muthu S, Gangadaran P, Ahn BC. Exosomal delivery of GrpE-like 1 from synovial mesenchymal stem cells activates PINK1-mediated mitophagy for cartilage repair in osteoarthritis. World J Stem Cells 2025; 17(11): 114306 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i11/114306.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i11.114306 |
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