BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
3/15/2026 6:15:27 AM | Browse: 13 | Download: 23
 |
Received |
|
2025-09-18 02:31 |
|
Peer-Review Started |
|
2025-09-18 02:31 |
|
First Decision by Editorial Office Director |
|
2025-10-10 09:10 |
|
Return for Revision |
|
2025-10-10 09:10 |
|
Revised |
|
2025-10-19 14:45 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-01-05 02:41 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-01-05 09:39 |
|
Articles in Press |
|
2026-01-05 09:39 |
|
Edit the Manuscript by Language Editor |
|
2026-01-09 00:54 |
|
Typeset the Manuscript |
|
2026-02-28 06:47 |
|
Publish the Manuscript Online |
|
2026-03-15 06:15 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Abnormalities of liver sinusoidal endothelial cells in primary biliary cholangitis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Evangelos Thalassinos, George Notas, Costantinos Xidakis, Ioannis Drygiannakis, Ourania Sfakianaki, Ioannis Tsomidis and Elias Kouroumalis |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Elias Kouroumalis, Emeritus Professor, MD, PhD, Liver Research Laboratory, University of Crete Medical School, 13 Kalokerinou Street, Voutes, Heraklion 71003, Crete, Greece. kouroumi@uoc.gr |
| Key Words |
Primary biliary cholangitis; Sinusoidal endothelial cells; Endothelial markers; Endothelins; Endothelin receptors |
| Core Tip |
Liver sinusoidal endothelial cells (LSECs) are implicated in the pathogenesis of various liver diseases including primary biliary cholangitis (PBC). In the present study, we demonstrated that LSECs biomarkers are significantly altered in the serum of patients with PBC but also in patients with chronic hepatitis C virus. Moreover, we incubated the human endothelial cell line EA.hy926 with sera from patients with PBC and hepatitis C virus and found that the expression of endothelins and their receptors significantly fluctuated at different time points. Collectively, these findings indicate that LSECs may be implicated in the pathogenesis of PBC. |
| Publish Date |
2026-03-15 06:15 |
| Citation |
Thalassinos E, Notas G, Xidakis C, Drygiannakis I, Sfakianaki O, Tsomidis I, Kouroumalis E. Abnormalities of liver sinusoidal endothelial cells in primary biliary cholangitis. World J Exp Med 2026; 16(1): 114313 |
| URL |
https://www.wjgnet.com/2220-315x/full/v16/i1/114313.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v16.i1.114313 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
