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Articles Published Processes
3/6/2026 8:57:10 AM | Browse: 4 | Download: 11
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Received |
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2025-09-16 06:31 |
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Peer-Review Started |
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2025-09-16 06:31 |
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First Decision by Editorial Office Director |
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2025-10-11 05:37 |
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Return for Revision |
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2025-10-11 05:37 |
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Revised |
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2025-10-28 18:38 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-04 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-04 04:08 |
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Articles in Press |
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2026-01-04 04:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-29 01:11 |
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Publish the Manuscript Online |
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2026-03-06 08:57 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Minireviews |
| Article Title |
Pharmacological treatment of obsessive-compulsive disorder in children and adolescents: An overview
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Aarya K Rajalakshmi, Aditya K S Pawar and Raman Baweja |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Aarya K Rajalakshmi, MD, Department of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, United States. arajalakshmi@mgb.org |
| Key Words |
Obsessive-compulsive disorder; Psychopharmacology; Selective serotonin reuptake inhibitors; Antipsychotics; Glutamate modulators; Pediatric |
| Core Tip |
Pediatric obsessive-compulsive disorder is a common and impairing condition associated with significant distress. First-line treatment is cognitive-behavioral therapy with exposure/response prevention. For moderate-to-severe cases or when therapy is inaccessible, pharmacotherapy is used adjunctively. Selective serotonin reuptake inhibitors are the initial drugs of choice, with clomipramine as an effective but less tolerated alternative. For treatment-resistant cases, antipsychotic augmentation is a next-step option, though used cautiously due to side effects. Glutamate modulators represent an emerging augmenting strategy. This review outlines the current pharmacological approach, highlighting the ongoing need for newer, effective, and well-tolerated treatments. |
| Publish Date |
2026-03-06 08:57 |
| Citation |
Rajalakshmi AK, Pawar AKS, Baweja R. Pharmacological treatment of obsessive-compulsive disorder in children and adolescents: An overview. World J Clin Pediatr 2026; 15(1): 114315 |
| URL |
https://www.wjgnet.com/2219-2808/full/v15/i1/114315.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v15.i1.114315 |
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