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Publication Name World Journal of Gastroenterology
Manuscript ID 114347
Country Australia
Received
2025-09-16 11:34
Peer-Review Started
2025-09-16 11:34
First Decision by Editorial Office Director
2025-11-18 10:47
Return for Revision
2025-11-18 10:47
Revised
2025-11-24 08:20
Publication Fee Transferred
Second Decision by Editor
2025-12-05 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-12-05 08:04
Articles in Press
2025-12-05 08:04
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-12-30 09:35
Publish the Manuscript Online
2026-01-16 11:31
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Letter to the Editor
Article Title Inflammation, immunity, and gastric ulcer — clinical insights from routine haematology
Manuscript Source Invited Manuscript
All Author List Hui Wang and Shi-San Bao
ORCID
Author(s) ORCID Number
Hui Wang http://orcid.org/0000-0002-1440-8942
Shi-San Bao http://orcid.org/0000-0002-6687-3846
Funding Agency and Grant Number
Corresponding Author Shi-San Bao, Additional Professor, Pathology, Pathology, University of Sydney, Sydney, New South Wales 2006, Australia, Faculty of Medicine and Health The University of Sydney, Sydney 2006, New South Wales, Australia. profbao@hotmail.com
Key Words Inflammation; Immunity; Gastric ulcer; Systemic immune-inflammation index; Routine haematology
Core Tip Gastric ulcer remains a significant health concern with serious complications. This study shows that six complete blood count (CBC)-derived inflammatory indices—neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammatory response index (SIRI), and aggregate index of systemic inflammation—are associated with gastric ulcer, with SIRI demonstrating the strongest predictive value (area under the curve = 0.868). As CBC is widely available, inexpensive, and reproducible, these indices may serve as practical, non-invasive tools for identifying at-risk patients and supplementing traditional risk factors. The findings emphasise the role of systemic inflammation in gastric ulcer pathogenesis and warrant prospective validation.
Publish Date 2026-01-16 11:31
Citation

Wang H, Bao SS. Inflammation, immunity, and gastric ulcer — clinical insights from routine haematology. World J Gastroenterol 2026; 32(3): 114347

URL https://www.wjgnet.com/1007-9327/full/v32/i3/114347.htm
DOI https://dx.doi.org/10.3748/wjg.v32.i3.114347
Full Article (PDF) WJG-32-114347-with-cover.pdf
Manuscript File 114347_Auto_Edited_023226.docx
Answering Reviewers 114347-answering-reviewers.pdf
Audio Core Tip 114347-audio.m4a
Conflict-of-Interest Disclosure Form 114347-conflict-of-interest-statement.pdf
Copyright License Agreement 114347-copyright-assignment.pdf
Peer-review Report 114347-peer-reviews.pdf
Scientific Misconduct Check 114347-scientific-misconduct-check.png
Scientific Editor Work List 114347-scientific-editor-work-list.pdf
CrossCheck Report 114347-crosscheck-report.pdf