| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Metallic elements and their molecular roles in gastric cancer: Pathogenic mechanisms and therapeutic implications
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Li-Baihe Jing, Jie Liu, Zi-Hai Yang, Fei-Fei Yang, De-Gui Wang and Yu-Min Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chief Scientist Project of Gansu Province |
No. 22JR9KA002 |
| Project of Gansu Provincial Department of Education |
No. 2021jyjbgs-02 |
| Key Research and Development Program of Gansu Province |
No. 20ZD7FA003 |
| National Natural Science Foundation of Gansu Province |
No. 25JRRA582 |
| Project of Basic Scientific Research Business Expenses of Central Universities |
No. 561225004 |
| Second Hospital of Lanzhou University Internal Talent Recruitment Program Fund |
No. yjrckyqdj-2024-02 |
|
| Corresponding Author |
Yu-Min Li, Chief Physician, MD, PhD, Professor, The Second Hospital and Clinical Medical School, Lanzhou University, No. 82 Cuiying Gate, Lanzhou 730000, Gansu Province, China. liym@lzu.edu.cn |
| Key Words |
Gastric cancer; Metallomics; Trace element; Exposure; Metal-based therapies |
| Core Tip |
Metallomics, a study of metallic elements in biological systems, is critical for understanding gastric cancer (GC). It helps identify biomarkers for early diagnosis and offers insights into treatment strategies. Novel biomarkers like matrix metalloproteinases, ferritin, and zinc (Zn2+) finger proteins can improve the sensitivity and accuracy of GC diagnosis compared to conventional tumor markers. Role of metals in GC: (1) Iron: Altered iron metabolism is linked to GC progression and can serve as a prognostic marker; (2) Copper: Copper imbalances contribute to GC development, and supplementation may enhance therapeutic effects; (3) Zn2+: Zn2+ stability is essential for cell function, and imbalances may indicate GC risk; and (4) Calcium: Abnormal calcium signal transduction may promote the occurrence, migration, invasion and other aspects of GC and affect prognosis. Metallomics faces challenges in identifying and quantifying metal-related biomarkers, dealing with low concentrations of elements, and overcoming issues with drug resistance. Advancements in analytical techniques and combining metal-based drugs with traditional therapies could improve GC diagnosis and treatment outcomes. |
| Publish Date |
2026-02-03 06:28 |
| Citation |
Jing LB, Liu J, Yang ZH, Yang FF, Wang DG, Li YM. Metallic elements and their molecular roles in gastric cancer: Pathogenic mechanisms and therapeutic implications. World J Gastrointest Oncol 2026; 18(2): 114351 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i2/114351.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i2.114351 |
