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2/11/2015 5:55:00 PM | Browse: 946 | Download: 1476
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 11436
Country/Territory Japan
Received
2014-05-21 21:24
Peer-Review Started
2014-05-21 23:01
To Make the First Decision
2014-06-27 12:00
Return for Revision
2014-07-07 09:59
Revised
2014-07-15 09:03
Second Decision
2015-01-14 09:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-01-20 16:53
Articles in Press
2015-01-20 16:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-02-07 20:33
Publish the Manuscript Online
2015-02-11 17:31
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Rabeprazole is effective for bile reflux oesophagitis after total gastrectomy in a rat model
Manuscript Source Unsolicited Manuscript
All Author List Naoki Hashimoto
Funding Agency and Grant Number
Corresponding Author Naoki Hashimoto, MD, PhD, School of Medicine, Kinki University, 377-2 Ohnohigashi, Oosaka-sayama-shi, Osaka 589-8511, Japan. gojigen000@gmail.com
Key Words Oesophagoduodenostomy; Reflux oesoph­agitis; Proton pump inhibitor; Rabeprazole
Core Tip To elucidate the effect of proton pump inhibitor (PPI, rabeparazole) on reflux oesophagitis. Sixteen 8-week-old male Wistar rats were studied. They were performed oesophagoduodenostomy of total gastrectomy to induce oesophageal reflux of biliary and pancreatic juice. Five rats were performed the sham operation (Sham). On post-operative day 7, they were treated with saline (Control) (n = 8) or PPI (rabeprazole, 30 mg/kg per day, ip) (n = 8) for 2 wk. On post-operative 21, all rats were sacrificed and each oesophagus was evaluated histologically. Oesophageal injury was evaluated by macroscopic and microscopic findings as well as the expression of cyclooxygenase-2 (COX2). We measured bile acid in the oesophageal lumen and the common bile duct. The macroscopic ulcer score and microscopic ulcer length of the control group were significantly higher compared to those of the rabeprazole- treated group. The expression of COX2 was significantly increased according to the immunostaining in the control group compared to rabeprazole- treated group. Although there was no difference between the control and PPI groups in the total bile acid in the common bile duct, the bile acid activity in the oesophageal lumen was significantly decreased in the rabeprazole- treated group due to augmentation of the duodenal motor complex. With this model, rabeprazole is good effect for reflux oesophagitis after total gastrectomy from bile reflux.
Publish Date 2015-02-11 17:31
Citation Hashimoto N. Rabeprazole is effective for bile reflux oesoph­agitis after total gastrectomy in a rat model. World J Gastrointest Pathophysiol 2015; 6(1): 23-28
URL http://www.wjgnet.com/2150-5330/full/v6/i1/23.htm
DOI http://dx.doi.org/10.4291/wjgp.v6.i1.23
Full Article (PDF) WJGP-6-23.pdf
Full Article (Word) WJGP-6-23.doc
Manuscript File 11436-Review.docx
Answering Reviewers 11436-Answering reviewers.pdf
Biostatistics Review Certificate 11436-Biostatistics.pdf
Conflict-of-Interest Disclosure Form 11436-Conflict-of-interest statement.pdf
Copyright License Agreement 11436-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 11436-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 11436-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 11436-Language certificate.docx
Peer-review Report 11436-Peer review(s).pdf
Scientific Misconduct Check 11436-CrossCheck.jpg
Scientific Editor Work List 11436-Scientific editor work list.pdf