Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	11436
Country	Japan

Received	2014-05-21 21:24
Peer-Review Started	2014-05-21 23:01
To Make the First Decision	2014-06-27 12:00
Return for Revision	2014-07-07 09:59
Revised	2014-07-15 09:03
Second Decision	2015-01-14 09:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-01-20 16:53
Articles in Press	2015-01-20 16:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-07 20:33
Publish the Manuscript Online	2015-02-11 17:31

ISSN	2150-5330 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Rabeprazole is effective for bile reflux oesophagitis after total gastrectomy in a rat model
Manuscript Source	Unsolicited Manuscript
All Author List	Naoki Hashimoto
Funding Agency and Grant Number
Corresponding Author	Naoki Hashimoto, MD, PhD, School of Medicine, Kinki University, 377-2 Ohnohigashi, Oosaka-sayama-shi, Osaka 589-8511, Japan. gojigen000@gmail.com
Key Words	Oesophagoduodenostomy; Reflux oesoph­agitis; Proton pump inhibitor; Rabeprazole
Core Tip	To elucidate the effect of proton pump inhibitor (PPI, rabeparazole) on reflux oesophagitis. Sixteen 8-week-old male Wistar rats were studied. They were performed oesophagoduodenostomy of total gastrectomy to induce oesophageal reflux of biliary and pancreatic juice. Five rats were performed the sham operation (Sham). On post-operative day 7, they were treated with saline (Control) (n = 8) or PPI (rabeprazole, 30 mg/kg per day, ip) (n = 8) for 2 wk. On post-operative 21, all rats were sacrificed and each oesophagus was evaluated histologically. Oesophageal injury was evaluated by macroscopic and microscopic findings as well as the expression of cyclooxygenase-2 (COX2). We measured bile acid in the oesophageal lumen and the common bile duct. The macroscopic ulcer score and microscopic ulcer length of the control group were significantly higher compared to those of the rabeprazole- treated group. The expression of COX2 was significantly increased according to the immunostaining in the control group compared to rabeprazole- treated group. Although there was no difference between the control and PPI groups in the total bile acid in the common bile duct, the bile acid activity in the oesophageal lumen was significantly decreased in the rabeprazole- treated group due to augmentation of the duodenal motor complex. With this model, rabeprazole is good effect for reflux oesophagitis after total gastrectomy from bile reflux.
Publish Date	2015-02-11 17:31
Citation	Hashimoto N. Rabeprazole is effective for bile reflux oesoph­agitis after total gastrectomy in a rat model. World J Gastrointest Pathophysiol 2015; 6(1): 23-28
URL	http://www.wjgnet.com/2150-5330/full/v6/i1/23.htm
DOI	http://dx.doi.org/10.4291/wjgp.v6.i1.23

Full Article (PDF)	WJGP-6-23.pdf
Full Article (Word)	WJGP-6-23.doc
Manuscript File	11436-Review.docx
Answering Reviewers	11436-Answering reviewers.pdf
Biostatistics Review Certificate	11436-Biostatistics.pdf
Conflict-of-Interest Disclosure Form	11436-Conflict-of-interest statement.pdf
Copyright License Agreement	11436-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	11436-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	11436-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	11436-Language certificate.docx
Peer-review Report	11436-Peer review(s).pdf
Scientific Misconduct Check	11436-CrossCheck.jpg
Scientific Editor Work List	11436-Scientific editor work list.pdf