| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinicopathologic and prognostic relevance of ARID1A protein loss in colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Li Wei, De-Shen Wang, Shao-Yan Xi, Wen-Jing Wu, Dong-Liang Chen, Zhao-Lei Zeng, Rui-Yu Wang, Ya-Xin Huang, Ying Jin, Feng Wang, Miao-Zhen Qiu, Hui-Yan Luo, Dong-Sheng Zhang and Rui-Hua Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National High-tech R&D Program of China (863 Program) |
2012AA02A506 |
| National Natural Science Foundation of China |
81372570 |
| Science and Technology Foundation of Guangdong Province |
2012B031800088 |
| Science and Technology Foundation of Guangdong Province |
C2011019 |
|
| Corresponding Author |
Rui-Hua Xu, MD, PhD, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dong Feng Road East, Guangzhou 510060, Guangdong Province, China. xurh@sysucc.org.cn |
| Key Words |
AT-rich interactive domain 1A; Switching defective/sucrose non-fermenting complexes; Colorectal cancer; Clinicopathologic characteristics; Prognosis |
| Core Tip |
AT-rich interactive domain 1A (ARID1A) (BAF250A) is a member of the switching defective/sucrose non-fermenting (BAF) complexes, which remodel nucleosomes. ARID1A gene mutation and protein loss have been detected in many human cancers. However, research on their clinical association in colorectal cancer is limited and requires further exploration. We found that ARID1A loss was not rare in primary colorectal cancer tumors (25.8%), and it was associated with clinicopathologic characteristics in colorectal cancer patients and with survival in stage Ⅳ patients. |
| Publish Date |
2015-01-06 09:08 |
| Citation |
Wei XL, Wang DS, Xi SY, Wu WJ, Chen DL, Zeng ZL, Wang RY, Huang YX, Jin Y, Wang F, Qiu MZ, Luo HY, Zhang DS, Xu RH. Clinicopathologic and prognostic relevance of ARID1A protein loss in colorectal cancer. World J Gastroenterol 2014; 20(48): 18404-18412 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i48/18404.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i48.18404 |
