BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
2/14/2026 6:34:07 AM | Browse: 72 | Download: 184
 |
Received |
|
2025-09-17 06:27 |
|
Peer-Review Started |
|
2025-09-17 06:27 |
|
First Decision by Editorial Office Director |
|
2025-10-10 07:45 |
|
Return for Revision |
|
2025-10-10 07:45 |
|
Revised |
|
2025-10-24 17:54 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2025-12-15 02:37 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-12-16 02:41 |
|
Articles in Press |
|
2025-12-16 02:41 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-02-04 02:30 |
|
Publish the Manuscript Online |
|
2026-02-14 06:34 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Synergistic mesenchymal and neural stem cell therapy: Advancing neurorestoration in cerebral infarction
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Noura A A Ebrahim, Moamen O Othman, Neveen S Tahoun, Thoraya A Farghaly and Soliman M A Soliman |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Noura A A Ebrahim, Department of Oncologic Pathology, National Cancer Institute, Cairo University, 1st Kasr Alainy Street, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com |
| Key Words |
Mesenchymal stem cells; Neural stem cells; Co-transplantation; Cerebral infarction; Stroke recovery; Angiogenesis; Neurotrophic factors; Regenerative medicine; Neurorestoration; Cell therapy |
| Core Tip |
The combination of mesenchymal stem cells and neural stem cells offers a biologically synergistic strategy for stroke repair. Mesenchymal stem cells release angiogenic and immunomodulatory factors - such as vascular endothelial growth factor and platelet-derived growth factor - that promote vascular regeneration and temper inflammation, while neural stem cells directly replace lost neural cells and stimulate neuroplasticity. Recent clinical evidence indicates that co-transplantation not only improves functional outcomes but also elevates vascular endothelial growth factor and basic fibroblast growth factor levels, suggesting enhanced vascular remodeling and neural circuit repair. This “cell-cocktail” concept may represent a transformative approach to addressing the multifactorial nature of cerebral infarction and advancing precision regenerative medicine. |
| Publish Date |
2026-02-14 06:34 |
| Citation |
Ebrahim NAA, Othman MO, Tahoun NS, Farghaly TA, Soliman SMA. Synergistic mesenchymal and neural stem cell therapy: Advancing neurorestoration in cerebral infarction. World J Stem Cells 2026; 18(2): 114372 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i2/114372.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i2.114372 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
