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Articles Published Processes
2/14/2026 6:34:07 AM | Browse: 1 | Download: 0
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Received |
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2025-09-17 06:27 |
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Peer-Review Started |
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2025-09-17 06:27 |
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First Decision by Editorial Office Director |
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2025-10-10 07:45 |
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Return for Revision |
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2025-10-10 07:45 |
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Revised |
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2025-10-24 17:54 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-15 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-16 02:41 |
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Articles in Press |
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2025-12-16 02:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-04 02:30 |
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Publish the Manuscript Online |
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2026-02-14 06:34 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Synergistic mesenchymal and neural stem cell therapy: Advancing neurorestoration in cerebral infarction
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Noura A A Ebrahim, Moamen O Othman, Neveen S Tahoun, Thoraya A Farghaly and Soliman M A Soliman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Noura A A Ebrahim, Department of Oncologic Pathology, National Cancer Institute, Cairo University, 1st Kasr Alainy Street, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com |
| Key Words |
Mesenchymal stem cells; Neural stem cells; Co-transplantation; Cerebral infarction; Stroke recovery; Angiogenesis; Neurotrophic factors; Regenerative medicine; Neurorestoration; Cell therapy |
| Core Tip |
The combination of mesenchymal stem cells and neural stem cells offers a biologically synergistic strategy for stroke repair. Mesenchymal stem cells release angiogenic and immunomodulatory factors - such as vascular endothelial growth factor and platelet-derived growth factor - that promote vascular regeneration and temper inflammation, while neural stem cells directly replace lost neural cells and stimulate neuroplasticity. Recent clinical evidence indicates that co-transplantation not only improves functional outcomes but also elevates vascular endothelial growth factor and basic fibroblast growth factor levels, suggesting enhanced vascular remodeling and neural circuit repair. This “cell-cocktail” concept may represent a transformative approach to addressing the multifactorial nature of cerebral infarction and advancing precision regenerative medicine. |
| Publish Date |
2026-02-14 06:34 |
| Citation |
Ebrahim NAA, Othman MO, Tahoun NS, Farghaly TA, Soliman SMA. Synergistic mesenchymal and neural stem cell therapy: Advancing neurorestoration in cerebral infarction. World J Stem Cells 2026; 18(2): 114372 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i2/114372.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i2.114372 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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