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Articles Published Processes
3/12/2026 12:25:40 PM | Browse: 1 | Download: 0
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Received |
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2025-09-18 03:04 |
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Peer-Review Started |
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2025-09-18 03:04 |
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First Decision by Editorial Office Director |
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2025-10-10 03:14 |
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Return for Revision |
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2025-10-10 03:14 |
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Revised |
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2025-10-24 03:43 |
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Publication Fee Transferred |
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2025-11-19 13:30 |
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Second Decision by Editor |
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2026-01-22 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-22 06:35 |
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Articles in Press |
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2026-01-22 06:35 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-25 06:05 |
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Publish the Manuscript Online |
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2026-03-12 12:25 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Anti-EGFR treatment resistance in patients with wild-type RAS metastatic colorectal cancer: Three case reports
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Wang, Qian Pei and Nan-Hui Yu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nan-Hui Yu, Associate Professor, PhD, Department of Gastrointestinal Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. yunanhui@csu.edu.cn |
| Key Words |
Anti-EGFR therapy; Colorectal cancer; Molecular mechanisms; Heterogeneity; Case report |
| Core Tip |
In this study, 3 wild-type RAS metastatic colorectal cancer patients with anti-EGFR resistance were analyzed. Key findings: Acquired resistance is associated with KRAS mutation/HER-2 amplification and primary resistance is associated with metastatic KRAS mutation (tumor heterogeneity). These findings suggest essential genetic profiling of primary/metastatic lesions (pyrosequencing for KRAS/NRAS/BRAF/PIK3CA and IHC+FISH for HER-2) and HER-2-targeted therapy for overexpression. |
| Publish Date |
2026-03-12 12:25 |
| Citation |
Wang J, Pei Q, Yu NH. Anti-EGFR treatment resistance in patients with wild-type RAS metastatic colorectal cancer: Three case reports. World J Gastrointest Oncol 2026; 18(3): 114379 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i3/114379.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i3.114379 |
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