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Articles Published Processes
12/15/2025 9:46:08 AM | Browse: 3 | Download: 0
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Received |
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2025-09-18 03:54 |
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Peer-Review Started |
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2025-09-23 05:59 |
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First Decision by Editorial Office Director |
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2025-10-10 03:54 |
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Return for Revision |
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2025-10-10 03:54 |
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Revised |
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2025-10-22 14:43 |
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Publication Fee Transferred |
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2025-10-26 10:58 |
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Second Decision by Editor |
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2025-11-10 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-10 03:45 |
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Articles in Press |
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2025-11-10 03:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-03 00:38 |
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Publish the Manuscript Online |
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2025-12-15 09:46 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Immune activation induced by dysregulated lipid metabolism in the pathogenesis of type 2 diabetes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hao-Yu Yang, Yu Wei, Qin Mao and Lin-Hua Zhao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences |
No. CI2023C024YL |
| Noncommunicable Chronic Diseases-National Science and Technology Major Project |
No. 2023ZD0509300 |
| Metabolic Diseases Research Special Program |
No. DXZX-05-02 |
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| Corresponding Author |
Qin Mao, College of Chinese Medicine, Bozhou University, No. 2266 Tangwang Avenue, Bozhou 236000, Anhui Province, China. mq961216@163.com |
| Key Words |
Type 2 diabetes mellitus; Insulin resistance; Lipid metabolism disorders; Cross-organ communication; Immunity |
| Core Tip |
Type 2 diabetes mellitus (T2DM) is driven by insulin resistance and β-cell dysfunction. This review highlights the innovative concept of “immune-metabolic coupling”, where dysregulated lipid metabolism (dyslipidemia) causes lipotoxicity, activating immune cells and triggering chronic inflammation that disrupts insulin signaling across multiple organs. We focus on the cross-organ communication network that perpetuates T2DM and argue that future research must target this immunometabolic crosstalk to move beyond managing the disease and toward restoring long-term immunological and metabolic homeostasis. |
| Publish Date |
2025-12-15 09:46 |
| Citation |
Yang HY, Wei Y, Mao Q, Zhao LH. Immune activation induced by dysregulated lipid metabolism in the pathogenesis of type 2 diabetes. World J Diabetes 2025; 16(12): 114395 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i12/114395.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i12.114395 |
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