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Articles Published Processes
12/25/2025 8:27:20 AM | Browse: 0 | Download: 0
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Received |
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2025-09-18 02:21 |
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Peer-Review Started |
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2025-09-18 02:21 |
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First Decision by Editorial Office Director |
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2025-09-30 07:53 |
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Return for Revision |
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2025-09-30 07:53 |
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Revised |
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2025-10-04 14:00 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-29 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-29 05:53 |
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Articles in Press |
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2025-10-29 05:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-11 03:28 |
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Publish the Manuscript Online |
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2025-12-25 08:27 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Very early recurrence after pancreatic cancer resection: Unmasking the "biological R2" enigma and rethinking prognostic paradigms
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Peng Wan, Shi-Qiong Zhou and Qing-Hua Ke |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Qing-Hua Ke, Chief Physician, PhD, Department of Chemoradiotherapy, Jingzhou No. 1 People's Hospital and First Affiliated Hospital of Yangtze University, No. 10 Tianhu Road, Shashi District, Jingzhou 434000, Hubei Province, China. 3803354759@qq.com |
| Key Words |
Pancreatic ductal adenocarcinoma; Very early recurrence; Biological R2 resection; Risk stratification; Prognostic factors |
| Core Tip |
Very early recurrence (VER) in pancreatic ductal adenocarcinoma (PDAC), a "biological R2 resection," occurs when macroscopically complete surgery fails to stop aggressive tumor progression. Martlı et al’s study of 303 PDAC patients identified G3 tumors (strongest predictor), pancreatic head location (contrary to prior assumptions), and elevated red cell distribution width as VER predictors, with VER doubling the 6-month mortality. These findings urge a shift to risk-stratified PDAC management, but the study’s retrospective, single-center design and lack of molecular data limit conclusions. Future research should validate predictors, test risk-stratified strategies, and explore VER’s molecular drivers. |
| Publish Date |
2025-12-25 08:27 |
| Citation |
Wan P, Zhou SQ, Ke QH. Very early recurrence after pancreatic cancer resection: Unmasking the "biological R2" enigma and rethinking prognostic paradigms. World J Gastrointest Surg 2025; 17(12): 114403 |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i12/114403.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i12.114403 |
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